Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | FPR2 | P25090 | 3/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7177458 | 0.91 | MMP8 (0.52) | MMP8FPR2MMP1MMP3CTSS | |
| SCHEMBL7174696 | 0.87 | MMP8 (0.48) | MMP8CTSSRENALDH1A1TACR2 | |
| SCHEMBL7172621 | 0.85 | MMP8 (0.46) | MMP8MMP1MMP3CTSSREN | |
| SCHEMBL7174231 | 0.83 | MMP8 (0.45) | MMP8MMP1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL7173722 | 0.81 | FCER2 (0.57) | MMP8MMP1MMP3MMP2MMP9 | |
| SCHEMBL7170637 | 0.80 | ALOX15 (0.45) | MMP8MMP1MMP3CTSSMAPT | |
| SCHEMBL1825413 | 0.76 | MMP8 (0.71) | MMP8MMP1MMP3CTSSALDH1A1 | |
| SCHEMBL7169041 | 0.74 | MEN1 (0.44) | MMP1MMP3KMT2AMEN1MMP2 | |
| SCHEMBL7306891 | 0.73 | ALDH1A1 (0.43) | MMP8MMP1MMP3CTSSALDH1A1 | |
| SCHEMBL7173680 | 0.71 | ALDH1A1 (0.41) | MMP8CTSSALDH1A1SMN1; SMN2TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6576628-B1 | Matrix metalloprotease inhibitors; arthritis, corneal ulcers, arteriosclerosis | ROCHE DIAGNOSTICS GMBH (DE) | 2003-06-10 | — | — | US | disclosed |
| EP-1005449-B1 | 3-ARYL-SUCCINAMIDO-HYDROXAMIC ACIDS, METHODS FOR PRODUCING SAID ACIDS AND MEDICAMENTS CONTAINING THE SAME | ROCHE DIAGNOSTICS GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| EP-0897908-A1 | 3-Aryl-succinamido-hydroxamic acids, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1999-02-24 | — | — | EP | disclosed |