⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12482346 | 0.70 | BRPF1 (0.30) | — | |
| SCHEMBL631735 | 0.69 | KIF11 (0.30) | — | |
| SCHEMBL6604232 | 0.69 | — | — | |
| SCHEMBL20278 | 0.69 | CTNNB1 (0.31) | — | |
| SCHEMBL7342799 | 0.67 | — | — | |
| SCHEMBL1040319 | 0.62 | ALDH1A1 (0.39) | — | |
| SCHEMBL9077845 | 0.61 | AKR1B1 (0.32) | — | |
| SCHEMBL1450407 | 0.60 | KDM4E (0.44) | — | |
| SCHEMBL2297398 | 0.59 | ALDH1A1 (0.33) | — | |
| SCHEMBL1147445 | 0.57 | PKM (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1367056-A1 | Drugs that enhance synaptic responses mediated by AMPA receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2003-12-03 | — | — | EP | disclosed |
| EP-1156043-B1 | Drugs that enhance synaptic responses mediated by ampa receptors | UNIV CALIFORNIA (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-0651746-B1 | DRUGS THAT ENHANCE SYNAPTIC RESPONSES MEDIATED BY AMPA RECEPTORS | UNIV CALIFORNIA (US) | 2002-03-27 | — | — | EP | disclosed |
| EP-1156043-A2 | Drugs that enhance synaptic responses mediated by ampa receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-11-21 | — | — | EP | disclosed |
| US-5891876-A | ALPHA-AMINO-3-HYDROXY-5-METHYL-ISOXAZOLE-4-PROPIONIC ACID (AMPA); DRUGS THAT ENHANCE THESE RECEPTOR CURRENTS WILL FACILITATE COMMUNICATION IN BRAIN NETWORKS RESPONSIBLE FOR PERCEPTUAL-MOTOR INTEGRATION AND HIGHER ORDER BEHAVIORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-04-06 | — | — | US | disclosed |
| US-5852008-A | Heteroatom substituted benzoyl derivatives that enhance synaptic response mediated by receptors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-22 | — | — | US | disclosed |