Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 10/20 | 0.37 |
| ▸ | BRAF | P15056 | 6/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | AADAC | P22760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205909 | 0.76 | PGR (0.35) | AR | |
| Laflunimus SCHEMBL9234178 | 0.75 | DHODH (0.67) | KDRBRAFUSP30LMNAEPHX2 | |
| Laflunimus SCHEMBL29677348 | 0.75 | DHODH (0.67) | KDRBRAFUSP30LMNAEPHX2 | |
| Laflunimus SCHEMBL21132 | 0.75 | DHODH (0.67) | KDRBRAFUSP30LMNAEPHX2 | |
| Laflunimus SCHEMBL22908 | 0.75 | DHODH (0.67) | KDRBRAFUSP30LMNAEPHX2 | |
| SCHEMBL13770863 | 0.74 | MAPT (0.42) | LMNACYP2C19SMN1; SMN2DHODHPOLB | |
| SCHEMBL21369 | 0.74 | EPHX1 (0.48) | ALDH1A1LMNATSHRMAPK1HTT | |
| SCHEMBL25134544 | 0.71 | ALDH1A1 (0.40) | IDO1KDRARALDH1A1LMNA | |
| SCHEMBL17100730 | 0.70 | DHODH (0.49) | KDRBRAFARUSP30ALDH1A1 | |
| SCHEMBL21539519 | 0.70 | DHODH (0.49) | KDRBRAFARUSP30ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566395-B1 | Therapy of proliferative disorders, such as cancers, blood vessel disorders and fibrotic disorders by administering N-(3-methyl-4- trifluoromethylphenyl) 2-cyano-2-(cycloalkylcarbonyl)acetamide compounds | BIOMEDICINES, INC. | 2003-05-20 | — | — | US | disclosed |