Sugi Predict

Sugi Predict / Compounds / SCHEMBL7180935

SCHEMBL7180935

SCHEMBL7180935

COc1cc(OC)c(C(=O)C(C(=O)OOC(C)OC)c2ccccc2)c(OC)c1.O=[PH3]

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 4/20 0.37
▸ CYP3A4 P08684 2/20 0.37
▸ MAPT P10636 2/20 0.37
▸ TP53 P04637 1/20 0.37
▸ ATM Q13315 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37
▸ MEN1 O00255 3/20 0.37
▸ L3MBTL1 Q9Y468 2/20 0.36
▸ TDP1 Q9NUW8 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.36
▸ HPGD P15428 1/20 0.36
▸ LMNA P02545 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ MAPK1 P28482 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ ABCG2 Q9UNQ0 1/20 0.34
▸ POLB P06746 1/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ MAOA P21397 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7177979 0.90 CA12 (0.41) KMT2AMEN1L3MBTL1ALDH1A1HPGD
SCHEMBL7183694 0.84 KMT2A (0.45) KMT2ACYP3A4MAPTTP53ATM
SCHEMBL7180203 0.83 TDP1 (0.41) KMT2ACYP3A4MAPTTP53ATM
SCHEMBL7177751 0.82 ALDH1A1 (0.38) KMT2AMAPTMEN1L3MBTL1ALDH1A1
SCHEMBL7189356 0.81 L3MBTL1 (0.35) KMT2AMEN1L3MBTL1ALDH1A1LMNA
SCHEMBL7175984 0.81 ALDH1A1 (0.40) KMT2ACYP3A4MAPTTP53ATM
SCHEMBL7175831 0.81 L3MBTL1 (0.42) KMT2ACYP3A4MAPTMEN1L3MBTL1
SCHEMBL7189265 0.81 MMP8 (0.49) KMT2ACYP3A4MAPTTP53ATM
SCHEMBL27554103 0.80 KMT2A (0.46) KMT2ACYP3A4MAPTTP53ATM
SCHEMBL7185733 0.80 KMT2A (0.39) KMT2ACYP3A4MAPTTP53ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 KMT2A 1586/4885CYP3A4 1652/4885MAPT 4870/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 KMT2A 956/4885CYP3A4 1881/4885MAPT 4859/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.