Sugi Predict

Sugi Predict / Compounds / SCHEMBL7182652

SCHEMBL7182652

SCHEMBL7182652

CCc1ccc(C(=O)c2ccccc2)c(CC)c1[PH](=O)C(=O)c1c(C)cc(C)c(C)c1C

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS2 P35354 2/20 0.35
▸ PTGS1 P23219 1/20 0.35
▸ HPGD P15428 2/20 0.33
▸ MAPK1 P28482 2/20 0.33
▸ MAPT P10636 1/20 0.33
▸ CNR2 P34972 2/20 0.32
▸ SRD5A2 P31213 1/20 0.32
▸ CYP2C8 P10632 1/20 0.32
▸ CYP2C9 P11712 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ USP2 O75604 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ KEAP1 Q14145 1/20 0.32
▸ NFE2L2 Q16236 1/20 0.32
▸ ABCB1 P08183 2/20 0.31
▸ ALDH1A1 P00352 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ CYP1A2 P05177 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180120 0.89 LMNA (0.37) PTGS2PTGS1HPGDMAPK1MAPT
SCHEMBL7188210 0.86 PTGS2 (0.35) PTGS2PTGS1HPGDMAPK1MAPT
SCHEMBL7187668 0.86 TDP1 (0.35) PTGS2PTGS1HPGDMAPK1MAPT
SCHEMBL7190332 0.82 RORC (0.35) PTGS2PTGS1MAPTCYP2C9GAA
SCHEMBL7182859 0.82 NPSR1 (0.36) PTGS2HPGDMAPK1MAPTSRD5A2
SCHEMBL7180907 0.81 L3MBTL1 (0.38) PTGS2PTGS1MAPK1MAPTCNR2
SCHEMBL7180474 0.80 HTT (0.38) HPGDMAPK1MAPTCYP2C9KDM4E
SCHEMBL7181622 0.79 NPSR1 (0.34) PTGS2HPGDMAPTCYP2C8CYP2C9
SCHEMBL7175283 0.79 MAPT (0.42) HPGDMAPK1MAPTKDM4EMEN1
SCHEMBL7177195 0.79 POLB (0.43) HPGDMAPK1MAPTKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 PTGS2 3909/4885PTGS1 3066/4885HPGD 3983/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 PTGS2 3871/4885PTGS1 3435/4885HPGD 4041/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.