Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 1/20 | 0.47 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 6/20 | 0.41 |
| ▸ | GABRD | O14764 | 6/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 6/20 | 0.41 |
| ▸ | GABRE | P78334 | 6/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 6/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7183528 | 0.92 | MAT2A (0.56) | MAT2ATNKS2LRRK2GABRPGABRD | |
| SCHEMBL7190954 | 0.84 | MAP3K11 (0.39) | MAT2ATNKS2LRRK2GABRPGABRD | |
| SCHEMBL7190679 | 0.79 | MAPT (0.53) | MAT2AMEN1LMNAKMT2AL3MBTL1 | |
| SCHEMBL27252266 | 0.77 | TNKS2 (0.50) | MAT2ATNKS2LRRK2GABRPGABRD | |
| SCHEMBL31435021 | 0.77 | MEN1 (0.62) | MAT2ATNKS2LRRK2PGRMEN1 | |
| SCHEMBL10720 | 0.76 | IMPDH2 (0.47) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15558879 | 0.75 | GABRP (0.42) | LRRK2GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL7190963 | 0.74 | MAT2A (0.47) | MAT2ATNKS2TNKS | |
| Hydrochloric Acid SCHEMBL3671410 | 0.74 | IMPDH2 (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL20302464 | 0.74 | L3MBTL1 (0.46) | TNKS2PGRMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |