Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 8/20 | 0.38 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.37 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.37 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.37 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.37 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.37 |
| ▸ | ADCY7 | P51828 | 1/20 | 0.37 |
| ▸ | ADCY2 | Q08462 | 1/20 | 0.37 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.37 |
| ▸ | ADCY4 | Q8NFM4 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.36 |
| ▸ | HTR2C | P28335 | 7/20 | 0.35 |
| ▸ | HTR2A | P28223 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL718879 | 0.87 | PDGFRB (0.36) | DRD2HTR2BPDGFRBPDGFRAEGFR | |
| SCHEMBL719123 | 0.81 | DRD2 (0.44) | DRD2HTR2BADCY6ADCY3ADCY9 | |
| SCHEMBL720033 | 0.77 | NCF1 (0.42) | DRD2HTR2BADCY6ADCY3ADCY9 | |
| SCHEMBL721292 | 0.76 | PDGFRB (0.60) | HTR2BPDGFRBPDGFRAHTR2CHTR2A | |
| SCHEMBL719120 | 0.76 | ALDH1A1 (0.52) | DRD2HTR2BADCY6ADCY3ADCY9 | |
| SCHEMBL719753 | 0.75 | HTR2C (0.42) | DRD2HTR2BADCY6ADCY3ADCY9 | |
| SCHEMBL722016 | 0.75 | DRD2 (0.40) | DRD2HTR2BADCY6ADCY3ADCY9 | |
| SCHEMBL721453 | 0.72 | DRD2 (0.49) | DRD2HTR2BADCY6ADCY3ADCY9 | |
| SCHEMBL720637 | 0.72 | ADCY6 (0.50) | DRD2HTR2BADCY6ADCY3ADCY9 | |
| Hydrochloric Acid SCHEMBL722803 | 0.70 | ADCY6 (0.48) | DRD2HTR2BADCY6ADCY3ADCY9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053168-A1 | FUSED BENZOAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2012-03-01 | — | — | US | claimed |
| WO-2010096384-A2 | FUSED BENZAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2010-08-26 | — | — | WO | claimed |
| US-20120053168-A1 | FUSED BENZOAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053168-A1 | FUSED BENZOAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2012-03-01 | — | — | US | disclosed |
| US-20120053168-A1 | FUSED BENZOAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2010096384-A2 | FUSED BENZAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | TARGACEPT, INC. (US) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053168-A1 | FUSED BENZOAZEPINES AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | CHRNA2, CHRNA5, CHRNA10 | DRD2 282/4885HTR2B 268/4885ADCY6 1033/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.