Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 5/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.44 |
| ▸ | LYN | P07948 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7187168 | 0.81 | EGFR (0.49) | EGFRFGFR2FLT3IMPDH2IMPDH1 | |
| SCHEMBL2543646 | 0.81 | ADRA2A (0.41) | EGFR | |
| SCHEMBL7369210 | 0.79 | IMPDH2 (0.59) | EGFRFGFR2FLT3IMPDH2IMPDH1 | |
| SCHEMBL2543648 | 0.78 | ADRA2A (0.53) | SYKPIK3CA | |
| SCHEMBL5527077 | 0.75 | PRKCQ (0.51) | EGFRFGFR2FLT3IMPDH2IMPDH1 | |
| SCHEMBL1643102 | 0.74 | FGFR2 (0.57) | EGFRFGFR2FLT3FLT1KDR | |
| SCHEMBL2975972 | 0.73 | GRM4 (0.54) | EGFRFGFR2FLT3IMPDH2IMPDH1 | |
| SCHEMBL7547492 | 0.73 | IMPDH2 (0.48) | EGFRIMPDH2IMPDH1PRKCQGABRP | |
| SCHEMBL27252329 | 0.73 | TNF (0.40) | SYKPIK3CA | |
| SCHEMBL1641747 | 0.72 | FGFR2 (0.67) | EGFRFGFR2FLT3FLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6582351-B1 | Benzimidazole heterocyclic compounds having pharmacological activities, and their use as a medicament for treatment or prevention of diseases mediated by cGMP-PDE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |