Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.48 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7185783 | 0.73 | EGFR (0.53) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| SCHEMBL30389000 | 0.67 | IMPDH2 (1.00) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| SCHEMBL91366 | 0.67 | IMPDH2 (1.00) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| Hydrochloric Acid SCHEMBL27803164 | 0.66 | IMPDH2 (0.96) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| SCHEMBL28194905 | 0.66 | IMPDH2 (0.96) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| SCHEMBL5531542 | 0.65 | IMPDH2 (0.44) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| SCHEMBL5531535 | 0.65 | IMPDH2 (0.44) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| Pyrimidine SCHEMBL28222789 | 0.64 | IMPDH2 (0.75) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| SCHEMBL7369210 | 0.63 | IMPDH2 (0.59) | IMPDH2IMPDH1GABRPGABRDGABRA1 | |
| SCHEMBL298150 | 0.63 | RIPK1 (0.69) | IMPDH2IMPDH1RIPK1LRRK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196391-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001005770-A1 | BENZIMIDAZOLONE DERIVATIVES AND THEIR USE AS PHOSPHODIESTERASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-01-25 | — | — | WO | disclosed |