SCHEMBL718626

SCHEMBL718626

c1ccc([N]c2ccccn2)nc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 3/20 0.56
ADRA2B P18089 3/20 0.56
ADRA2C P18825 3/20 0.56
MAOA P21397 2/20 0.56
MAOB P27338 2/20 0.56
PLAU P00749 1/20 0.56
KDM4E B2RXH2 2/20 0.48
LMNA P02545 2/20 0.48
POLB P06746 2/20 0.48
CYP1A2 P05177 1/20 0.48
CCR1 P32246 1/20 0.48
CCR5 P51681 1/20 0.48
CCR8 P51685 1/20 0.48
METAP1 P53582 1/20 0.48
BLM P54132 1/20 0.48
HIF1A Q16665 1/20 0.48
DOHH Q9BU89 1/20 0.48
P4HTM Q9NXG6 1/20 0.48
ALDH1A1 P00352 3/20 0.44
MAPT P10636 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1921855 0.85 MAOA (0.65) ADRA2AADRA2BADRA2CMAOAMAOB
SCHEMBL275526 0.82 MAOA (0.77) ADRA2AADRA2BADRA2CMAOAMAOB
SCHEMBL29785641 0.82 MAOA (0.77) ADRA2AADRA2BADRA2CMAOAMAOB
SCHEMBL2470956 0.82 MAOA (0.77) ADRA2AADRA2BADRA2CMAOAMAOB
SCHEMBL2874213 0.81 ALDH1A1 (0.48) ADRA2AADRA2BADRA2CMAOAMAOB
SCHEMBL337735 0.80
SCHEMBL2557888 0.80 MAOA (0.74) ADRA2AADRA2BADRA2CMAOAMAOB
SCHEMBL3194915 0.80
Benzene SCHEMBL10803509 0.80 MAOA (0.82) ADRA2AADRA2BADRA2CMAOAMAOB
SCHEMBL8136475 0.79 ADRA2A (0.44) ADRA2AADRA2BADRA2CMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 357 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114773347-A Benzimidazole compound based on ortho-substitution and application thereof 宁波卢米蓝新材料有限公司 2022-07-22 CN claimed
CN-114736208-A Benzimidazole compound based on multi-donor substitution and application thereof 宁波卢米蓝新材料有限公司 2022-07-12 CN claimed
CN-114507219-A Organic compound based on naphthalimide and application thereof 宁波卢米蓝新材料有限公司 2022-05-17 CN claimed
CN-113666918-A Organic electroluminescent compound with high thermal stability and organic electroluminescent device 南京高光半导体材料有限公司 2021-11-19 CN claimed
CN-113493446-A Carbazolyl-based organic electroluminescent compound and organic electroluminescent device 南京高光半导体材料有限公司 2021-10-12 CN claimed
CN-113024497-A Organic electroluminescent compound and organic electroluminescent device containing same 南京高光半导体材料有限公司 2021-06-25 CN claimed
US-6235730-B1 ANTICHOLESTEROL AGENT, ANTILIPEMIC AGENT JAPAN TOBACCO, INC. (JP) 2001-05-22 US claimed
EP-0970954-A1 3-PIPERIDYL-4-OXOQUINAZOLINE DERIVATIVES AND MEDICINCAL COMPOSITIONS CONTAINING THE SAME JAPAN TOBACCO INC. (JP) 2000-01-12 EP claimed
EP-0412699-B1 Nitrosothiol derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1994-04-27 EP claimed
EP-0412699-A2 Nitrosothiol derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1991-02-13 EP claimed
US-11980092-B2 Organic electroluminescence element HODOGAYA CHEMICAL CO., LTD. (JP) 2024-05-07 US disclosed
US-11944004-B2 Organic electroluminescence element HODOGAYA CHEMICAL CO., LTD. (JP) 2024-03-26 US disclosed
US-11925107-B2 Organic electroluminescent device HODOGAYA CHEMICAL CO., LTD. (JP) 2024-03-05 US disclosed
US-11925114-B2 Indenocarbazole compound and organic electroluminescence device HODOGAYA CHEMICAL CO., LTD. (JP) 2024-03-05 US disclosed
US-20240032321-A1 ORGANIC ELECTROLUMINESCENT ELEMENT HODOGAYA CHEMICAL CO., LTD. (JP) 2024-01-25 US disclosed
EP-0475264-A1 Electrophotographic photoreceptor Mitsubishi Chemical Corporation (JP) 1992-03-18 EP disclosed
US-5080991-A ELECTROPHOTOGRAPHIC PHOTORECEPTOR WITH A HYDRAZONE MITSUBISHI KASEI CORPORATION (JP) 1992-01-14 US disclosed
EP-0435165-A1 Electrophotographic plate Mitsubishi Chemical Corporation (JP) 1991-07-03 EP disclosed
EP-0414185-A2 Electrophotographic photoreceptor Mitsubishi Chemical Corporation (JP) 1991-02-27 EP disclosed
EP-0273426-A2 Enamine derivatives, production thereof and electrophotographic plates containing the same Hitachi Chemical Co., Ltd. (JP) 1988-07-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11925107-B2 Organic electroluminescent device LEF1, KCNN2, AXIN2 ADRA2A 596/4885ADRA2B 783/4885ADRA2C 1444/4885
US-11925114-B2 Indenocarbazole compound and organic electroluminescence device OXA1L, KCNJ1, ABCB1 ADRA2A 2992/4885ADRA2B 731/4885ADRA2C 2296/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.