Sugi Predict

Sugi Predict / Compounds / SCHEMBL7187015

SCHEMBL7187015

SCHEMBL7187015

O=POCCOC(C(=O)c1c(C(F)(F)F)cccc1C(F)(F)F)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ FFAR4 Q5NUL3 1/20 0.34
▸ ACP3 P15309 1/20 0.34
▸ PPARG P37231 2/20 0.34
▸ TXNRD1 Q16881 1/20 0.34
▸ MCL1 Q07820 1/20 0.33
▸ POLB P06746 2/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ CYP1A2 P05177 1/20 0.32
▸ CYP3A4 P08684 1/20 0.32
▸ CYP2C9 P11712 1/20 0.32
▸ CYP2C19 P33261 1/20 0.32
▸ MRGPRX4 Q96LA9 1/20 0.32
▸ IDO1 P14902 1/20 0.32
▸ TDO2 P48775 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ ITGA4 P13612 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7181535 0.81 L3MBTL1 (0.40) ALDH1A1SMN1; SMN2POLBKDM4ECYP1A2
SCHEMBL7183753 0.81 ALDH1A1 (0.35) ALDH1A1SMN1; SMN2POLBMEN1KMT2A
SCHEMBL7181341 0.79 CA12 (0.42) ALDH1A1SMN1; SMN2POLBMEN1KMT2A
SCHEMBL7183312 0.77 LMNA (0.38) ALDH1A1SMN1; SMN2MEN1KMT2ACYP1A2
SCHEMBL7177121 0.76 TRPM4 (0.38) ALDH1A1SMN1; SMN2POLBCYP1A2CYP3A4
SCHEMBL7735689 0.76 LMNA (0.35) ALDH1A1SMN1; SMN2POLBMEN1KMT2A
SCHEMBL7176044 0.74 FABP4 (0.40) ALDH1A1POLBMEN1KMT2AITGA4
SCHEMBL7181149 0.74 HPGD (0.39) ALDH1A1POLBMEN1KMT2ACYP3A4
SCHEMBL7175788 0.72 ACP3 (0.41) ALDH1A1ACP3PPARGPOLBKDM4E
SCHEMBL7187322 0.71 PPARG (0.39) ALDH1A1SMN1; SMN2ACP3PPARGTXNRD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 ALDH1A1 3416/4885SMN1; SMN2 2939/4885FFAR4 1611/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 ALDH1A1 3984/4885SMN1; SMN2 3105/4885FFAR4 1526/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.