Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.70 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.57 |
| ▸ | UBE2M | P61081 | 4/20 | 0.55 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6864004 | 0.85 | ALDH1A1 (0.56) | SIGMAR1ACKR3ALDH1A1 | |
| SCHEMBL6865191 | 0.83 | CHRM2 (0.57) | SIGMAR1ACKR3ALDH1A1KDM4EDRD4 | |
| SCHEMBL6865563 | 0.83 | FAAH (0.61) | SIGMAR1ALDH1A1KDM4EGAADRD4 | |
| SCHEMBL9849508 | 0.82 | SMYD3 (0.75) | SIGMAR1ACKR3ALDH1A1 | |
| SCHEMBL6865166 | 0.82 | SIGMAR1 (0.67) | SIGMAR1ALDH1A1GAA | |
| SCHEMBL7112457 | 0.81 | ALDH1A1 (0.57) | ACKR3ALDH1A1 | |
| SCHEMBL6864686 | 0.80 | ACKR3 (0.58) | SIGMAR1ACKR3ALDH1A1KDM4E | |
| SCHEMBL12310740 | 0.80 | ALDH1A1 (0.63) | ALDH1A1GAA | |
| SCHEMBL6862228 | 0.80 | SIGMAR1 (0.67) | SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL6863613 | 0.79 | KDM4E (0.62) | SIGMAR1ACKR3ALDH1A1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817489-A | BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES | ISIS PHARMACEUTICALS, INC. (US) | 1998-10-06 | — | — | US | claimed |
| US-6660466-B1 | Reacting reactive appendage compounds such as meta benzylic compounds or alpha-amide compounds with scaffold molecules having reactive functionalities and contacting the intermediate library with a reducing agent | ISIS PHARMACEUTICALS, INC. | 2003-12-09 | — | — | US | disclosed |
| US-6150129-A | USEFUL AS ANTIBACTERIAL AND OTHER PHARMACEUTICAL AGENTS AND AS INTERMEDIATES FOR PREPARATION OF OTHER PHARMACEUTICAL AGENTS | ISIS PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-5922872-A | BACTERICIDES AND DRUGS | ISIS PHARMACEUTICALS, INC. (US) | 1999-07-13 | — | — | US | disclosed |
| US-5817489-A | BACTERICIDES, OR CHEMICAL INTERMEDIATES THEREOF; DRUG LIBRARIES | ISIS PHARMACEUTICALS, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5798360-A | ANTIBACTERIAL AGENTS | ISIS PHARMACEUTICALS, INC. (US) | 1998-08-25 | — | — | US | disclosed |
| US-5780241-A | ALTERING ELECTROCHEMICAL PROPERTIES BY DECYCLIZATION | ISIS PHARMACEUTICALS, INC. (US) | 1998-07-14 | — | — | US | disclosed |
| US-5731438-A | BACTERICIDES; DRUGS | ISIS PHARMACEUTICALS, INC. (US) | 1998-03-24 | — | — | US | disclosed |