Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | DRD2 | P14416 | 2/20 | 0.67 |
| ▸ | HTR2A | P28223 | 2/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | DRD4 | P21917 | 1/20 | 0.67 |
| ▸ | ACHE | P22303 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | HTR2C | P28335 | 1/20 | 0.67 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.67 |
| ▸ | CCKBR | P32239 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | HRH1 | P35367 | 1/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.67 |
| ▸ | DRD3 | P35462 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL718326 | 0.92 | DRD2 (0.69) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| Methyl Alcohol SCHEMBL718775 | 0.92 | HTR1A (0.71) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| SCHEMBL1545055 | 0.88 | ABCB11 (0.86) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| Methyl Alcohol SCHEMBL929694 | 0.84 | ABCB11 (0.66) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| Methyl Alcohol SCHEMBL142049 | 0.84 | ABCB11 (0.66) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| Methyl Alcohol SCHEMBL718327 | 0.84 | HTR1A (0.76) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| Alcohol SCHEMBL142048 | 0.84 | DRD2 (0.66) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| SCHEMBL9101152 | 0.84 | HTR1A (0.68) | HTR1ADRD2HTR2AABCB11CHRM2 | |
| SCHEMBL22149696 | 0.84 | DRD2 (0.76) | HTR1ADRD2HTR2AACHEHTR2C | |
| Alcohol SCHEMBL8713382 | 0.83 | HTR1A (0.69) | HTR1ADRD2HTR2AADRA2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458507-B1 | Antipsychotic treatment based on SNP genotype | VANDA PHARMACEUTICALS, INC. (US) | 2016-10-04 | — | — | US | claimed |
| US-20160265060-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. | 2016-09-15 | — | — | US | claimed |
| US-20100292211-A1 | ANTIPSYCHOTIC TREATMENT BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. | 2010-11-18 | — | — | US | claimed |
| US-20100249188-A1 | PREDICTION OF QT PROLONGATION BASED ON SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. | 2010-09-30 | — | — | US | claimed |
| US-9243295-B2 | Antipsychotic treatment based on DRD2 or ANKK1 SNP genotype | Vanda Pharmaceutical, Inc. (US) | 2016-01-26 | — | — | US | disclosed |
| US-9057104-B2 | Antipsychotic treatment based on DRD2 or ANKK1 SNP genotype | VANDA PHARMACEUTICALS, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-20120053207-A1 | ANTIPSYCHOTIC TREATMENT BASED ON DRD2 OR ANKK1 SNP GENOTYPE | VANDA PHARMACEUTICALS, INC. (US) | 2012-03-01 | — | — | US | disclosed |