Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL6377525 | 0.87 | CYP2C19 (0.35) | TSHRALDH1A1CYP2C19GBA2 | |
| Methyl Alcohol SCHEMBL4271767 | 0.86 | CYP2C19 (0.38) | TSHRTDP1CYP2C19 | |
| SCHEMBL18191 | 0.86 | CYP2C19 (0.42) | TSHRTDP1CYP2C19 | |
| Methyl Alcohol SCHEMBL20601076 | 0.83 | CYP2C19 (0.36) | CYP2C19 | |
| Ammonia Solution, Strong SCHEMBL27688316 | 0.82 | CYP2C19 (0.40) | TSHRTDP1CYP2C19 | |
| Hydrochloric Acid SCHEMBL8858515 | 0.82 | CYP2C19 (0.40) | TSHRTDP1CYP2C19 | |
| SCHEMBL28557000 | 0.82 | CYP2C19 (0.40) | TSHRTDP1CYP2C19 | |
| Ether SCHEMBL1414943 | 0.80 | TSHR (0.35) | TSHRALDH1A1TDP1CYP2C19 | |
| SCHEMBL1530161 | 0.80 | — | — | |
| SCHEMBL6032267 | 0.79 | NUDT1 (0.32) | TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037324-B2 | Biarylmethyl heterocycles | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-07-16 | — | — | US | disclosed |
| EP-3478672-B1 | BIARYLMETHYL HETEROCYCLES | UNIV MONTREAL (CA) | 2024-04-10 | — | — | EP | disclosed |
| US-20230045357-A1 | BIARYLMETHYL HETEROCYCLES | Université de Montréal (CA) | 2023-02-09 | — | — | US | disclosed |
| US-20190202808-A1 | BIARYLMETHYL HETEROCYCLES | BRISTOL-MYERS SQUIBB COMPANY | 2019-07-04 | — | — | US | disclosed |
| EP-2464634-B1 | REGIOSELECTIVE PREPARATION OF 2-AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | BOEHRINGER INGELHEIM INT (DE) | 2016-11-30 | — | — | EP | disclosed |
| US-9040564-B2 | Stabilized composition | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-05-26 | — | — | US | disclosed |
| US-8933227-B2 | Selective synthesis of functionalized pyrimidines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-01-13 | — | — | US | disclosed |
| EP-2464634-A1 | REGIOSELECTIVE PREPARATION OF 2 -AMINO-5-TRIFLUOROMETHYLPYRIMIDINE DERIVATIVES | Boehringer Ingelheim International GmbH (DE) | 2012-06-20 | — | — | EP | disclosed |
| US-8124780-B2 | Benzimidazole compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-02-28 | — | — | US | disclosed |
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-04 | — | — | US | disclosed |
| WO-2005095379-A2 | CRYSTALLINE METHANESULFONIC ACID ADDITION SALTS OF IMATINIB | INSTYTUT FARMACEUTYCZNY (PL) | 2005-10-13 | — | — | WO | disclosed |
| US-6906083-B2 | 4-substituted piperidine compound | EISAI CO., LTD. (JP) | 2005-06-14 | — | — | US | disclosed |
| US-20050026895-A1 | 4-Substituted piperidine compound | EISAI CO., LTD. | 2005-02-03 | — | — | US | disclosed |
| US-20030166925-A1 | 4-Substituted piperidine compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1308781-A2 | Cyclic sulfonium and sulfoxonium photoacid generators and photoresists containing them | Shipley Co. L.L.C. (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1300395-A1 | 4-SUBSTITUTED PIPERIDINE COMPOUND | Eisai Co., Ltd. (JP) | 2003-04-09 | — | — | EP | disclosed |
| US-5624922-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0597540-B1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC (US) | 1996-06-05 | — | — | EP | disclosed |
| US-5380721-A | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0597540-A1 | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents | STERLING WINTHROP INC. (US) | 1994-05-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190499-A1 | SELECTIVE SYNTHESIS OF FUNCTIONALIZED PYRIMIDINES | DPYD, TYMS, UMPS | TSHR 2996/4885ALDH1A1 727/4885TDP1 623/4885 |
| US-20190202808-A1 | BIARYLMETHYL HETEROCYCLES | ARRB1, ADRB2, ADRB1 | TSHR 429/4885ALDH1A1 919/4885TDP1 4458/4885 |
| US-20050026895-A1 | 4-Substituted piperidine compound | ACHE, CHRM2, CHRM1 | TSHR 1527/4885ALDH1A1 80/4885TDP1 2020/4885 |
| US-20030166925-A1 | 4-Substituted piperidine compound | ACHE, CHRM4, CHRM1 | TSHR 2161/4885ALDH1A1 66/4885TDP1 1433/4885 |
| US-12037324-B2 | Biarylmethyl heterocycles | ARRB1, ADRB2, ADRB1 | TSHR 429/4885ALDH1A1 919/4885TDP1 4458/4885 |
| US-20230045357-A1 | BIARYLMETHYL HETEROCYCLES | ARRB1, ADRB2, ADRB1 | TSHR 429/4885ALDH1A1 919/4885TDP1 4458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.