Sugi Predict

Sugi Predict / Compounds / SCHEMBL7189207

SCHEMBL7189207

SCHEMBL7189207

CC(C)(C)c1cc(C(C)(C)C)c(C(=O)Pc2ccccc2)c(C(C)(C)C)c1.[LiH]

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 1/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ ALOX5 P09917 3/20 0.38
▸ PTGS2 P35354 3/20 0.38
▸ RXRA P19793 5/20 0.37
▸ RXRB P28702 5/20 0.37
▸ RXRG P48443 3/20 0.37
▸ GLRA3 O75311 1/20 0.35
▸ GLRB P48167 1/20 0.35
▸ KCNK9 Q9NPC2 1/20 0.34
▸ MAPT P10636 2/20 0.33
▸ NR5A2 O00482 1/20 0.33
▸ NR5A1 Q13285 1/20 0.33
▸ APEX1 P27695 1/20 0.33
▸ TDP1 Q9NUW8 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ ESRRG P62508 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7180014 0.86 RXRB (0.39) RXRARXRBRXRGKCNK9MAPT
SCHEMBL7188184 0.78 RXRB (0.42) CYP2C9ALOX5RXRARXRBRXRG
SCHEMBL10350353 0.75 ALOX5 (0.48) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL7183728 0.75 SRD5A2 (0.39) CYP2C9MAPTTDP1L3MBTL1KMT2A
SCHEMBL7189269 0.73 TSHR (0.39) TSHRRXRARXRBRXRGMAPT
SCHEMBL7189867 0.72 HDAC4 (0.39) RXRARXRBRXRGKCNK9KMT2A
SCHEMBL6466602 0.72 GLRA3 (0.57) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL7180020 0.71 GFER (0.34) CYP3A4CYP2C9TSHRCYP2C19MAPT
SCHEMBL5997574 0.70 NR5A2 (0.42) CYP1A2CYP3A4CYP2C9TSHRCYP2C19
SCHEMBL7177452 0.70 LMNA (0.37) L3MBTL1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6579663-B2 Chemical intermediates such as lithium 2,6-dimethylbenzoyl phenylphosphine for preparation of acylphosphines, acylphosphine oxides or acylphosphine sulfides CIBA SPECIALTY CHEMICALS CORPORATION 2003-06-17 — — US disclosed
US-20020107413-A1 Organometallic monoacylarylphosphines WOLF JEAN-PIERRE (CH) 2002-08-08 — — US disclosed
US-6399805-B2 SUCH AS LITHIUM 2,6-DIMETHYLBENZOYLPHENYLPHOSPHINE, USE AS PHOTOINITIATORS IN PHOTOCURABLE COMPOSITIONS SUCH AS FOR PHOTOGRAPHIC PRODUCTION OF RELIEF IMAGES CIBA SPECIALTY CHEMICALS CORPORATION 2002-06-04 — — US disclosed
US-20010031898-A1 Organometallic monoacylarylphosphines CIBA SPECIALTY CHEMICALS CORP. 2001-10-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020107413-A1 Organometallic monoacylarylphosphines CBR1, NAF1, DHCR24 CYP1A2 1595/4885CYP3A4 1652/4885CYP2C9 1094/4885
US-20010031898-A1 Organometallic monoacylarylphosphines NAF1, DHCR24, CBR1 CYP1A2 2020/4885CYP3A4 1881/4885CYP2C9 1606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.