SCHEMBL71912

SCHEMBL71912

O=C(O)Cc1cccc(Cl)c1O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 2/20 0.59
CXCL8 P10145 3/20 0.56
PTGS2 P35354 3/20 0.56
TTR P02766 2/20 0.56
AKR1B10 O60218 1/20 0.56
UGT1A9 O60656 1/20 0.56
TRPA1 O75762 1/20 0.56
ABCB11 O95342 1/20 0.56
MT-CO2 P00403 1/20 0.56
ALB P02768 1/20 0.56
UGT1A6 P19224 1/20 0.56
UGT1A1 P22309 1/20 0.56
PTGS1 P23219 1/20 0.56
CXCR1 P25024 1/20 0.56
ADRA1A P35348 1/20 0.56
AGTR2 P50052 1/20 0.56
NR1I3 Q14994 1/20 0.56
SLC22A6 Q4U2R8 1/20 0.56
NR1H4 Q96RI1 1/20 0.56
UGT1A7 Q9HAW7 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7937087 0.85 AKR1B1 (0.67) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL2547244 0.83 AKR1B1 (0.63) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL28094939 0.82 HSP90AA1 (0.47) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL9061930 0.82 SHBG (0.47) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL29933245 0.81 CXCL8 (0.65) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL194831 0.81 CXCL8 (0.65) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL27503091 0.81 FFAR1 (0.48) AKR1B1HSP90AA1
SCHEMBL11176738 0.80 CXCL8 (0.49) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL11124309 0.80 CXCL8 (0.77) AKR1B1CXCL8PTGS2TTRAKR1B10
SCHEMBL11691926 0.80 AKR1B1 (0.77) AKR1B1CXCL8PTGS2TTRAKR1B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8697847-B2 Protein purification using HCIC and ion exchange chromatography MEDAREX, L.L.C. (US) 2014-04-15 US claimed
US-20120165511-A1 PROTEIN PURIFICATION USING HCIC AND ION EXCHANGE CHROMATOGRAPHY MEDAREX, INC. 2012-06-28 US claimed
US-20090105465-A1 Protein Purification Using HCIC and Ion Exchange Chromatography MEDAREX, INC. (US) 2009-04-23 US claimed
EP-1869067-A1 PROTEIN PURIFICATION USING HCIC AMD ION EXCHANGE CHROMATOGRAPHY Medarex, Inc. (US) 2007-12-26 EP claimed
WO-2006110277-A1 PROTEIN PURIFICATION USING HCIC AMD ION EXCHANGE CHROMATOGRAPHY MEDAREX, INC. (US) 2006-10-19 WO claimed
EP-0783366-B1 CHROMATOGRAPHIC RESINS AND METHODS FOR USING SAME UNIV MASSEY (NZ) 2004-08-18 EP claimed
US-5945520-A RESIN OF SOLID SUPPORT MATRIX, SPACER ARM AND IONIZABLE FUNCTIONALITY; SPECIFICALLY DESIGNED TO BIND THE TARGET COMPOUND FROM AN AQUEOUS SOLUTION AT BOTH A LOW AND HIGH IONIC STRENGTH MASSEY UNIVERSITY (NZ) 1999-08-31 US claimed
US-5652348-A SOLID SUPPORT MATRIX, IONIZABLE LIGANDS SELECTED RELATIVE TO TARGET COMPOUND MASSEY UNIVERSITY (NZ) 1997-07-29 US claimed
EP-0783366-A1 CHROMATOGRAPHIC RESINS AND METHODS FOR USING SAME MASSEY UNIVERSITY (NZ) 1997-07-16 EP claimed
WO-1996009116-A1 CHROMATOGRAPHIC RESINS AND METHODS FOR USING SAME MASSEY UNIVERSITY (NZ) 1996-03-28 WO claimed
EP-2632562-B1 METHODS FOR CAPTURING VIRUS LIKE PARTICLES FROM PLANTS USING EXPANDED BED CHROMATOGRAPHY PHILIP MORRIS PRODUCTS SA (CH) 2020-08-05 EP disclosed
EP-3662053-A1 CRYPTIC METABOLITES AND METHOD FOR ACTIVATING SILENT BIOSYNTHETIC GENE CLUSTERS IN DIVERSE MICROORGANISMS The Trustees of Princeton University (US) 2020-06-10 EP disclosed
WO-2019027877-A1 CRYPTIC METABOLITES AND METHOD FOR ACTIVATING SILENT BIOSYNTHETIC GENE CLUSTERS IN DIVERSE MICROORGANISMS THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-02-07 WO disclosed
US-9056894-B2 Methods for capturing virus like particles from plants using expanded bed chromatogrpahy PHILIP MORRIS PRODUCTS S.A. (CH) 2015-06-16 US disclosed
US-20150152179-A1 ANTIBODIES WITH DECREASED DEAMIDATION PROFILES MEDIMMUNE, LLC (US) 2015-06-04 US disclosed
US-5652348-A SOLID SUPPORT MATRIX, IONIZABLE LIGANDS SELECTED RELATIVE TO TARGET COMPOUND MASSEY UNIVERSITY (NZ) 1997-07-29 US disclosed
EP-0783366-A1 CHROMATOGRAPHIC RESINS AND METHODS FOR USING SAME MASSEY UNIVERSITY (NZ) 1997-07-16 EP disclosed
EP-0773954-A1 HYDROPHOBIC CHROMATOGRAPHIC RESINS WITH IONIZABLE GROUPS MASSEY UNIVERSITY (NZ) 1997-05-21 EP disclosed
WO-1996009116-A1 CHROMATOGRAPHIC RESINS AND METHODS FOR USING SAME MASSEY UNIVERSITY (NZ) 1996-03-28 WO disclosed
WO-1996000735-A1 HYDROPHOBIC CHROMATOGRAPHIC RESINS WITH IONIZABLE GROUPS MASSEY UNIVERSITY (NZ) 1996-01-11 WO disclosed