Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8750089 | 0.90 | HPGD (0.40) | HPGDTDP1TAS1R3TAS1R1GAA | |
| Acetic Acid SCHEMBL7195816 | 0.87 | TDP1 (0.38) | HPGDTDP1TAS1R3TAS1R1GAA | |
| Iodide SCHEMBL7193211 | 0.82 | ACHE (0.46) | HPGDTDP1TAS1R3TAS1R1ACHE | |
| Hydrochloric Acid SCHEMBL7192461 | 0.82 | ACHE (0.46) | HPGDTDP1TAS1R3TAS1R1ACHE | |
| Bromide SCHEMBL7195821 | 0.82 | ACHE (0.46) | HPGDTDP1TAS1R3TAS1R1ACHE | |
| Succinic Acid SCHEMBL7193250 | 0.82 | HDAC3 (0.44) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| Succinic Acid SCHEMBL7195779 | 0.82 | RAB9A (0.41) | TDP1HDAC8HDAC6HDAC3HDAC4 | |
| Succinic Acid SCHEMBL7200763 | 0.82 | ALDH1A1 (0.36) | HPGDTDP1TAS1R3TAS1R1PARP1 | |
| Phosphoric Acid SCHEMBL7201609 | 0.81 | ACP3 (0.40) | HPGDTDP1TAS1R3TAS1R1ACHE | |
| Succinic Acid SCHEMBL679440 | 0.81 | CYP2C19 (0.50) | HDAC8HDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624173-B2 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | DOW CHEMICAL CO (US) | 2003-04-09 | — | — | EP | disclosed |
| EP-0624173-A1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS. | DOW CHEMICAL CO (US) | 1994-11-17 | — | — | EP | disclosed |
| WO-1993015126-A1 | PRECATALYZED CATALYST COMPOSITIONS, PROCESS FOR PREPARING RESINS | THE DOW CHEMICAL COMPANY (US) | 1993-08-05 | — | — | WO | disclosed |