Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29404889 | 0.91 | AGTR1 (0.50) | AGTR1AGTR2P2RX7ALDH1A1HTT | |
| SCHEMBL796 | 0.91 | AGTR1 (0.50) | AGTR1AGTR2P2RX7ALDH1A1HTT | |
| SCHEMBL10299418 | 0.90 | POLB (0.39) | AGTR1AGTR2ALDH1A1HTTPOLB | |
| SCHEMBL7384556 | 0.85 | AGTR1 (0.42) | AGTR1AGTR2P2RX7 | |
| SCHEMBL976147 | 0.85 | LMNA (0.47) | AGTR1AGTR2P2RX7ALDH1A1HTT | |
| SCHEMBL8791472 | 0.83 | AGTR1 (0.40) | AGTR1AGTR2ALDH1A1 | |
| SCHEMBL8791998 | 0.83 | AGTR1 (0.40) | AGTR1AGTR2PTGS2 | |
| SCHEMBL9235857 | 0.82 | MEN1 (0.42) | AGTR1AGTR2ALDH1A1HTTPOLB | |
| SCHEMBL29931185 | 0.82 | AGTR1 (0.44) | AGTR1AGTR2P2RX7ALDH1A1HTT | |
| SCHEMBL588221 | 0.82 | AGTR1 (0.44) | AGTR1AGTR2P2RX7ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268494-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | Merck Frosst Canada & Co. (CA) | 2003-01-02 | — | — | EP | disclosed |
| US-6498151-B2 | PROTEIN TYROSINE PHOSPHATASES INHIBITORS, ESPECIALLY AS ANTIDIABETIC AGENTS | MERCK FROSST CANADA & CO. (CA) | 2002-12-24 | — | — | US | disclosed |
| EP-0685470-B1 | Benzene derivatives and pharmaceutical composition | KUREHA CHEMICAL IND CO LTD (JP) | 2002-09-11 | — | — | EP | disclosed |
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | MERCK FROSST CANADA LTD. (CA) | 2002-07-11 | — | — | US | disclosed |
| WO-2001070753-A1 | SULFUR SUBSTITUTED ARYLDIFLUOROMETHYLPHOSPHONIC ACIDS AS PTP-1B INHIBITORS | MERCK FROSST CANADA & CO. (CA) | 2001-09-27 | — | — | WO | disclosed |
| US-5739131-A | TREATMENT OF KIDNEY DISORDERS; COMPOUNDS DO NOT AFFECT BLOOD PRESSURE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| US-5731310-A | KIDNEY DISEASE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1998-03-24 | — | — | US | disclosed |
| US-5696118-A | ADMINISTERING FOR TREATING KIDNEY DISEASE | KUREHA CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-12-09 | — | — | US | disclosed |
| EP-0665223-A1 | Antitumor agent, novel 3(2H)-pyridazinone derivatives and their preparation | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091104-A1 | Aryldifluoromethylphosphonic acids with sulfur-containing substituents as PTP-1B inhibitors | PTPRF, PTPRS, PTPRO | AGTR1 1427/4885AGTR2 2252/4885P2RX7 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.