Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9235857 | 0.90 | MEN1 (0.42) | LMNAHSD17B10ALDH1A1TSHRKMT2A | |
| SCHEMBL9025603 | 0.89 | MEN1 (0.41) | LMNAHSD17B10ALDH1A1TSHRKMT2A | |
| SCHEMBL8323797 | 0.89 | LMNA (0.39) | LMNAHSD17B10ALDH1A1TSHRKMT2A | |
| SCHEMBL8698703 | 0.88 | AGTR1 (0.47) | LMNAHSD17B10ALDH1A1TSHRKMT2A | |
| SCHEMBL9025749 | 0.85 | AGTR1 (0.43) | LMNAHSD17B10ALDH1A1TSHRKMT2A | |
| SCHEMBL7195878 | 0.85 | LMNA (0.43) | LMNAALDH1A1POLBHTTL3MBTL1 | |
| SCHEMBL3256000 | 0.85 | CA1 (0.43) | LMNAHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL7196989 | 0.85 | AGTR1 (0.41) | LMNAHSD17B10ALDH1A1TSHRPOLB | |
| SCHEMBL7611179 | 0.85 | MAOA (0.43) | LMNAHSD17B10ALDH1A1TSHRKMT2A | |
| SCHEMBL27347057 | 0.85 | LMNA (0.36) | LMNAHSD17B10ALDH1A1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 130 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2189457-A1 | Novel synthesis of irbesartan | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2010-05-26 | — | — | EP | claimed |
| US-20090216026-A1 | Novel synthesis of irbesartan | NISNEVICH GENNADY | 2009-08-27 | — | — | US | claimed |
| EP-2039693-A2 | Novel synthesis of irbesartan | Teva Pharmaceutical Industries Limited (IL) | 2009-03-25 | — | — | EP | claimed |
| EP-1931648-A2 | PROCESSES FOR THE SYNTHESIS OF 5-PHENYL -1 TRITYL-1H-TETRAZOLE | Teva Pharmaceutical Industries Ltd. (IL) | 2008-06-18 | — | — | EP | claimed |
| US-20080103312-A1 | Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole | TEVA PHARMACEUTICALS USA, INC. | 2008-05-01 | — | — | US | claimed |
| WO-2008027385-A2 | PROCESSES FOR THE SYNTHESIS OF 5-PHENYL -1 TRITYL-1H-TETRAZOLE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-03-06 | — | — | WO | claimed |
| CN-1759113-A | Novel synthesis method of irbesartan | TEVA PHARMA (IL) | 2006-04-12 | — | — | CN | claimed |
| US-20040192713-A1 | Novel synthesis of irbesartan | TEVA PHARMACEUTICALS USA, INC. | 2004-09-30 | — | — | US | claimed |
| US-10300471-B2 | Ruthenium-catalyzed synthesis of biaryl compounds in water | CHICAGO DISCOVERY SOLUTIONS, LLC | 2019-05-28 | — | — | US | disclosed |
| US-20160263565-A1 | RUTHENIUM-CATALYZED SYNTHESIS OF BIARYL COMPOUNDS IN WATER | CHICAGO DISCOVERY SOLUTIONS, LLC (US) | 2016-09-15 | — | — | US | disclosed |
| US-20160263565-A1 | RUTHENIUM-CATALYZED SYNTHESIS OF BIARYL COMPOUNDS IN WATER | CHICAGO DISCOVERY SOLUTIONS, LLC (US) | 2016-09-15 | — | — | US | disclosed |
| US-9216970-B2 | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216970-B2 | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216970-B2 | Dual-acting thiophene, pyrrole, thiazole and furan antihypertensive agents | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2015-12-22 | — | — | US | disclosed |
| EP-0846117-A1 | PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-06-10 | — | — | EP | disclosed |
| US-5760220-A | REACTING PROTECTED TETRAZOLYLPHENYL ZINC HALIDE WITH HALOPHENYLMETHYL PYRIDO/2,3-D/PYRIMIDONE IN PRESENCE OF PALLADIUM OR NICKEL CATALYST | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0782996-A1 | PROCESS FOR PRODUCING N-BIPHENYLMETHYLTHIADIAZOLINE DERIVATIVE OR SALT THEREOF AND INTERMEDIATE FOR PRODUCING THE SAME | WAKUNAGA SEIYAKU KABUSHIKI KAISHA (JP) | 1997-07-09 | — | — | EP | disclosed |
| WO-1996040684-A1 | PROCESS FOR PREPARATION OF BIPHENYL DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |
| US-5310929-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-05-10 | — | — | US | disclosed |
| WO-1994003435-A1 | PRODRUGS OF IMIDAZOLE CARBOXYLIC ACIDS AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080103312-A1 | Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole | REN, AGTR1, AGTR2 | LMNA 2439/4885HSD17B10 3027/4885ALDH1A1 897/4885 |
| US-10300471-B2 | Ruthenium-catalyzed synthesis of biaryl compounds in water | RUVBL2, RUVBL1, CYP2W1 | LMNA 3074/4885HSD17B10 1122/4885ALDH1A1 2208/4885 |
| US-20040192713-A1 | Novel synthesis of irbesartan | REN, AGTR1, AGTR2 | LMNA 3493/4885HSD17B10 1326/4885ALDH1A1 1102/4885 |
| US-20090216026-A1 | Novel synthesis of irbesartan | AGTR1, REN, AGTR2 | LMNA 3976/4885HSD17B10 2255/4885ALDH1A1 731/4885 |
| US-20160263565-A1 | RUTHENIUM-CATALYZED SYNTHESIS OF BIARYL COMPOUNDS IN WATER | RUVBL2, RUVBL1, CYP2W1 | LMNA 3074/4885HSD17B10 1122/4885ALDH1A1 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.