Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 8/20 | 0.46 |
| ▸ | HLA-DRB1 | P01911 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CASP9 | P55211 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5686901 | 0.92 | REN (0.46) | RENHLA-DRB1CASP1CTSKCTSB | |
| SCHEMBL5689425 | 0.91 | CASP1 (0.49) | RENHLA-DRB1CASP1OPRD1CTSK | |
| SCHEMBL5686703 | 0.86 | REN (0.42) | RENCTSKCTSBCTSD | |
| SCHEMBL5686572 | 0.85 | CASP1 (0.43) | RENCASP1CTSKCTSBCTSS | |
| SCHEMBL5686581 | 0.85 | CASP1 (0.43) | RENCASP1CTSKCTSBCTSS | |
| SCHEMBL5686920 | 0.80 | REN (0.52) | RENHLA-DRB1CASP1OPRD1CTSK | |
| SCHEMBL5686583 | 0.80 | CASP1 (0.53) | RENHLA-DRB1CASP1OPRD1CTSK | |
| SCHEMBL7198022 | 0.79 | OPRD1 (0.38) | RENHLA-DRB1CASP1OPRD1CTSK | |
| SCHEMBL5686595 | 0.78 | CASP1 (0.54) | RENHLA-DRB1CASP1OPRD1CTSK | |
| SCHEMBL2037696 | 0.77 | CASP1 (0.62) | RENHLA-DRB1CASP1OPRD1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6593300-B1 | Inhibitors of the interleukin-1 beta converting enzyme | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2003-07-15 | — | — | US | disclosed |
| EP-0979241-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998049189-A1 | (3R)-3-AMINO-4-CARBOXYBUTYRALDEHYDE DERIVATIVES INHIBITING THE RELEASE OF INTERLEUKIN-1/BETA | Gyógyszerkutató Intézet Kft. (HU) | 1998-11-05 | — | — | WO | disclosed |