SCHEMBL7198375

SCHEMBL7198375

C=CCc1ccc(-c2ccc(C#N)cc2)c(-c2ccccc2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 4/20 0.41
MAPT P10636 3/20 0.41
CNR2 P34972 3/20 0.41
GABRB2 P47870 3/20 0.41
GAA P10253 3/20 0.41
MEN1 O00255 2/20 0.41
CNR1 P21554 2/20 0.41
KMT2A Q03164 2/20 0.41
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
ALDH2 P05091 1/20 0.41
AKR1B1 P15121 1/20 0.41
HPGD P15428 1/20 0.41
PPARG P37231 1/20 0.41
PPARD Q03181 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ALOX5 P09917 3/20 0.40
GABRA5 P31644 2/20 0.40
GABRA3 P34903 2/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4620939 1.00 GABRA1 (0.41) GABRA1MAPTCNR2GABRB2GAA
SCHEMBL7194022 0.91 PTGDR2 (0.43) GABRA1MAPTCNR2GABRB2GAA
SCHEMBL9274282 0.86 GABRA1 (0.50) GABRA1MAPTCNR2GABRB2GAA
SCHEMBL11790701 0.85 MAP4K4 (0.47) MAPTALOX5KDM1A
SCHEMBL28248969 0.81 GABRA1 (0.53) GABRA1MAPTCNR2GABRB2GAA
SCHEMBL5573395 0.81 CYP19A1 (0.51) GABRA1MAPTCNR2GABRB2GAA
SCHEMBL8375669 0.81 CYP2A6 (0.55) GABRA1MAPTKDM4EALDH1A1GABRA5
SCHEMBL7213550 0.80 ALOX5 (0.43) GABRA1MAPTCNR2GABRB2GAA
SCHEMBL9364525 0.78 NPSR1 (0.37) GABRA1MAPTCNR2GABRB2GAA
SCHEMBL7779660 0.78 TSHR (0.47) ALDH1A1NPSR1POLBMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6511719-B2 Chiral structure element based on hydrobenzoin; two centers of chirality, high twisting power; liquid crystal displays; cholesteric texture displays MERCK PATENT GESELLSCHAFT (DE) 2003-01-28 US disclosed