Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28471616 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL276956 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL1097671 | 0.70 | CYP2A6 (0.42) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL4079696 | 0.70 | CYP2A6 (0.42) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL286416 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL2008998 | 0.70 | ALDH1A1 (0.42) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL4897405 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL1605255 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL21179481 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 | |
| SCHEMBL2012336 | 0.70 | ALDH1A1 (0.39) | ALDH1A1HSD17B10CYP2A6TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 183 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948633-B1 | 3 -HYDROXYFLAVONE DERIVATIVES FOR THE DETECTION AND THE QUANTIFICATION OF CELL APOPTOSIS | CENTRE NAT RECH SCIENT (FR) | 2011-08-10 | — | — | EP | claimed |
| US-7880021-B2 | reacting 6-bromomethyl-4'-(diethylamino)-3-hydroxyflavone with dodecylmethylamine to form the corresponding tertiary amine (4'-(diethylamino)-6-(dodecyl(methyl)aminomethyl)-3-hydroxyflavone); and reacting the product of step a. with propansultone; use in biomembrane studies; Alzheimer's disease, cancer | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2011-02-01 | — | — | US | claimed |
| US-20090269793-A1 | Compounds and Kits for the Detection and the Quantification of Cell Apoptosis | Centre National De La Recherche Scientifiique (CNRS) | 2009-10-29 | — | — | US | claimed |
| JP-2009511566-A | — | — | 2009-03-19 | — | — | JP | claimed |
| EP-1218383-B1 | BICYCLIC IMIDAZO-5-YL-AMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2008-11-05 | — | — | EP | claimed |
| EP-1948633-A2 | 3 -HYDROXYFLAVONE DERIVATIVES FOR THE DETECTION AND THE QUANTIFICATION OF CELL APOPTOSIS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2008-07-30 | — | — | EP | claimed |
| WO-2007057782-A2 | 3 -HYDROXYFLAVONE DERIVATIVES FOR THE DETECTION AND THE QUANTIFICATION OF CELL APOPTOSIS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-05-24 | — | — | WO | claimed |
| US-7153873-B2 | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines | GRUENENTHAL GMBH (DE) | 2006-12-26 | — | — | US | claimed |
| US-20060217378-A1 | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines | GRUENENTHAL GMBH (DE) | 2006-09-28 | — | — | US | claimed |
| US-7087607-B2 | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines | GRUENENTHAL GMBH (DE) | 2006-08-08 | — | — | US | claimed |
| CN-1065535-C | Pyrazolopyrimidines and pyrrolopyrimidines for treatment of neuronal and other disorders | PFIZER (US) | 2001-05-09 | — | — | CN | claimed |
| WO-2001027119-A2 | SUBSTANCE LIBRARY CONTAINING BICYCLIC IMIDAZO-5-YL-AMINES AND/OR BICYCLIC IMIDAZO-3-YL-AMINES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |
| WO-2001027118-A2 | BICYCLIC IMIDAZO-5-YL-AMINE DERIVATIVES | Grünenthal GmbH (DE) | 2001-04-19 | — | — | WO | claimed |
| US-6117887-A | ANTIPROLIFERATIVE AGENTS | CV THERAPEUTICS, INC. (US) | 2000-09-12 | — | — | US | claimed |
| US-5808162-A | Chiral unsymmetric diphosphine compound and transition metal complex containing the same as ligand | TAKASAGO INTERNATIONAL CORPORATION (JP) | 1998-09-15 | — | — | US | claimed |
| CN-1034175-C | pyrazolopyrimidines | PFIZER (US) | 1997-03-05 | — | — | CN | claimed |
| CN-1141297-A | Pyrazolopyrimidines and pyrrolopyrimidines for treatment of neuronal and other disorders | PFIZER (US) | 1997-01-29 | — | — | CN | claimed |
| EP-0754696-A1 | Chiral unsymmetric diphosphine compounds and transition metal complexes containing them as ligands | Takasago International Corporation (JP) | 1997-01-22 | — | — | EP | claimed |
| CN-1094048-A | Pyrazolopyrimidines | PFIZER (US) | 1994-10-26 | — | — | CN | claimed |
| US-4558038-A | HYPOTENSIVE AGENTS | USV PHARMACEUTICAL CORP. (US) | 1985-12-10 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060217378-A1 | Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines | HNMT, GRIK5, OPRK1 | ALDH1A1 394/4885HSD17B10 2101/4885CYP2A6 420/4885 |
| US-20090269793-A1 | Compounds and Kits for the Detection and the Quantification of Cell Apoptosis | BAX, CASP3, BCL2 | ALDH1A1 1876/4885HSD17B10 1409/4885CYP2A6 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.