SCHEMBL7199355

SCHEMBL7199355

Clc1cccc([Si](Cl)(Cl)Cl)c1-c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FABP4 P15090 8/20 0.44
FABP3 P05413 7/20 0.44
FABP5 Q01469 1/20 0.44
CYP2A6 P11509 1/20 0.41
PTGS1 P23219 2/20 0.38
PTGS2 P35354 2/20 0.38
RAB9A P51151 1/20 0.36
LMNA P02545 2/20 0.36
TSHR P16473 1/20 0.36
MAP2 P11137 1/20 0.35
CYP1A2 P05177 1/20 0.34
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34
GUSB P08236 1/20 0.34
HSD11B1 P28845 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
KMT2A Q03164 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308199 0.79 CYP2A6 (0.55) FABP4FABP3FABP5CYP2A6PTGS1
SCHEMBL5359524 0.79 CYP2A6 (0.41) CYP2A6PTGS1PTGS2RAB9ALMNA
SCHEMBL1225074 0.74 TSHR (0.50) CYP2A6RAB9ALMNATSHRCYP1A2
SCHEMBL4270859 0.71 CYP2A6 (0.65) FABP4FABP3FABP5CYP2A6PTGS1
SCHEMBL27715394 0.71 TSHR (0.56) FABP4FABP3FABP5CYP2A6LMNA
SCHEMBL2103502 0.70 TSHR (0.44) CYP2A6LMNATSHRCYP1A2MEN1
SCHEMBL11454164 0.70 MAPK1 (0.44) FABP4FABP3FABP5CYP2A6PTGS1
SCHEMBL28638926 0.70 CYP2A6 (0.44) FABP4FABP3FABP5CYP2A6PTGS1
SCHEMBL28364118 0.70 CYP2A6 (0.44) FABP4FABP3FABP5CYP2A6PTGS1
SCHEMBL20108554 0.70 FABP4 (0.53) FABP4FABP3FABP5CYP2A6PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0763001-B1 SELECTIVE PRODUCTION OF PARA-DIALKYL SUBSTITUTED BENZENES MOBIL OIL CORP (US) 1999-09-08 EP claimed
EP-0128721-B1 SILICA-MODIFIED CATALYST AND USE FOR SELECTIVE PRODUCTION OF PARA-DIALKYL SUBSTITUTED BENZENES MOBIL OIL CORPORATION (US) 1989-07-26 EP claimed
US-6541408-B2 Progressive temperature gradient stabilizes hydrorefining catalysts (metal-modified zeolite) to allow long duration of use and low by-product make EXXONMOBIL OIL CORP. 2003-04-01 US disclosed
US-20020091293-A1 Zeolite catalysts having stabilized hydrogenation-dehydrogenation function EXXONMOBIL OIL CORPORATION 2002-07-11 US disclosed
US-6346498-B1 PERMEATING METAL INTO MOLECULAR SIEVE; IN SITU SELECTIVATION WITH SILICON COMPOUND AND ROASTING; BY-PRODUCT INHIBITION EXXONMOBIL OIL CORPORATION 2002-02-12 US disclosed
US-6207871-B1 CONVERTING A HYDROCARBON FEEDSTREAM COMPRISING ETHYLBENZENE AND META-XYLENE OVER MOLECULAR SIEVE CATALYST UNDER ETHYLBENZENE CONVERSION CONDITIONS, MOBIL OIL CORPORATION 2001-03-27 US disclosed
US-4532368-A Passing mixture of phenol, ortho-alkylphenol, alkylating agent through zeolite catalyst, separating and recycling ortho-alkylphenols ETHYL CORPORATION (US) 1985-07-30 US disclosed
US-4444989-A Methylation of toluene to para-xylene catalyzed by crystalline silica E. I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-24 US disclosed
US-4283306-A CATALYTIC METHYLATION OF TOLUENE E. I. DU PONT DE NEMOURS AND COMPANY (US) 1981-08-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020091293-A1 Zeolite catalysts having stabilized hydrogenation-dehydrogenation function HDHD5, HSF1, HRH4 FABP4 1941/4885FABP3 2782/4885FABP5 2164/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.