Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 7/20 | 0.37 |
| ▸ | ADAM10 | O14672 | 4/20 | 0.37 |
| ▸ | MMP9 | P14780 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 4/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | USP5 | P45974 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7200489 | 0.88 | USP5 (0.44) | ADAMTS5MMP2ADAM10MMP9MMP13 | |
| SCHEMBL7202601 | 0.88 | MMP2 (0.49) | ADAMTS5ADAM17MMP2ADAM10MMP9 | |
| SCHEMBL7205721 | 0.88 | MMP13 (0.45) | HSD11B1MMP2MMP9MMP13MMP1 | |
| SCHEMBL7201610 | 0.88 | MMP2 (0.47) | ADAM17MMP2ADAM10MMP9MMP13 | |
| SCHEMBL7204170 | 0.86 | HTR2C (0.48) | ADAM17MMP2ADAM10MMP9MMP13 | |
| SCHEMBL7206963 | 0.84 | HTR2C (0.49) | MMP13MMP1 | |
| SCHEMBL7205654 | 0.83 | MMP13 (0.54) | MMP2MMP9MMP13MMP1MMP3 | |
| SCHEMBL7204092 | 0.82 | HDAC4 (0.40) | HSD11B1MMP2ADAM10MMP13ERBB2 | |
| SCHEMBL7204290 | 0.82 | MMP2 (0.46) | ADAM17MMP2ADAM10MMP13MMP1 | |
| SCHEMBL7205659 | 0.82 | TP53 (0.41) | HSD11B1ADAM17MMP2ADAM10MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608104-B2 | Antiarthritic agents; anticancer agents | PFIZER INC | 2003-08-19 | — | — | US | disclosed |
| US-20020019534-A1 | Gem substituted hydroxamic acids | PFIZER INC. | 2002-02-14 | — | — | US | disclosed |
| EP-1138680-A1 | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019534-A1 | Gem substituted hydroxamic acids | MMP14, TOP2A, ADAMTS1 | HSD11B1 1493/4885ADAMTS5 11/4885NPSR1 3387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.