Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 7/20 | 0.44 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | CDK1 | P06493 | 4/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5930324 | 0.83 | CCNE1 (0.44) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL6744537 | 0.78 | ADORA2A (0.55) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL10848639 | 0.76 | KDM4E (0.61) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL8493219 | 0.74 | TK1 (0.64) | ALDH1A1HSD17B10CYP3A4HIF1A | |
| SCHEMBL9388321 | 0.72 | CYP2C19 (0.47) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL17226007 | 0.72 | CDK1 (0.55) | CCNE1CDK2CDK1CCNB1ADORA2A | |
| SCHEMBL7272071 | 0.71 | CCNE1 (0.43) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL7272082 | 0.71 | CCNE1 (0.43) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL7057757 | 0.71 | CCNE1 (0.45) | CCNE1CDK2CDK1CCNB1CYP2C19 | |
| SCHEMBL7262136 | 0.70 | CYP3A4 (0.64) | CCNE1CDK2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6573378-B1 | 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine having a purity of greater than 95% by weight or it's sodium salt | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2003-06-03 | — | — | US | disclosed |
| US-5075445-A | GUANINE DERIVATIVES | BEECHAM GROUP P.L.C. (GB) | 1991-12-24 | — | — | US | disclosed |
| EP-0141927-A2 | Antiviral guanine derivatives | BEECHAM GROUP PLC (GB) | 1985-05-22 | — | — | EP | disclosed |