Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14158421 | 0.77 | DYRK1A (0.40) | DYRK1A | |
| SCHEMBL25318530 | 0.73 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL9911039 | 0.69 | DGAT1 (0.34) | DYRK1A | |
| SCHEMBL20798991 | 0.68 | KDM5A (0.45) | CRHR1 | |
| SCHEMBL11049763 | 0.67 | KDM5A (0.41) | — | |
| SCHEMBL4572140 | 0.66 | DGAT1 (0.37) | DYRK1A | |
| SCHEMBL5432578 | 0.66 | CRHR1 (0.55) | CRHR1 | |
| SCHEMBL3285613 | 0.66 | CDK8 (0.42) | CRHR1DYRK1A | |
| SCHEMBL19788662 | 0.66 | DGAT1 (0.35) | — | |
| SCHEMBL23869471 | 0.66 | CCNT1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010041673-A1 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | PFIZER INC. | 2001-11-15 | — | — | US | claimed |
| US-6589947-B1 | Treatment or prevention of Syndrome X in an animal, preferably a mammal including a human subject or a companion animal, using a corticotropin releasing factor (CRF) antagonist alone or together with a glucocorticoid receptor antagonist. | PFIZER INC. | 2003-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010041673-A1 | Combinations of corticotropin releasing factor antagonists and growth hormone secretagogues | CRH, GHSR, GHRHR | CRHR1 4/4885DYRK1A 3075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.