Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7201109 | 0.81 | METAP1 (0.45) | ALDH1A1DRD2DRD1DRD5DRD3 | |
| SCHEMBL28340252 | 0.80 | KDM4E (0.54) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL7980286 | 0.80 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL31192163 | 0.80 | ALDH1A1 (0.54) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| Methane SCHEMBL28300119 | 0.79 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL27407138 | 0.78 | PGR (0.42) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL8854649 | 0.78 | DRD2 (0.54) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL7196660 | 0.76 | MAPT (0.47) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL7941151 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL28841162 | 0.76 | KDM4E (0.50) | KDM4EALDH1A1MAPTRAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0942006-B1 | Catalyst for olefin polymer production and process for olefin polymer production employing the catalyst | TOSOH CORP (JP) | 2003-06-04 | — | — | EP | disclosed |
| EP-0709393-A2 | Olefin polymerization catalyst and process for producing olefin polymer | TOSOH CORPORATION (JP) | 1996-05-01 | — | — | EP | disclosed |