Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | LTA4H | P09960 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475821 | 0.91 | DRD2 (0.58) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL367677 | 0.89 | HRH3 (0.57) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL6228523 | 0.88 | MAPT (0.65) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL8778568 | 0.87 | HRH3 (0.60) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL3024482 | 0.87 | HRH3 (0.60) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL9570575 | 0.86 | DRD2 (0.65) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL9654053 | 0.84 | HRH3 (0.54) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL9570561 | 0.84 | HRH3 (0.69) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL5390369 | 0.84 | HRH3 (0.69) | KCNH2DRD2DRD4DRD3MAPT | |
| SCHEMBL535260 | 0.84 | LMNA (0.54) | KCNH2DRD2DRD4DRD3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108084179-B | Compound with spiro structure, preparation method and application thereof | 上海医药工业研究院 | 2021-02-05 | — | — | CN | claimed |
| CN-108084179-A | A kind of compound with spirane structure, its preparation method and application | 上海医药工业研究院 | 2018-05-29 | — | — | CN | claimed |
| CN-101171009-A | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3- receptor ligands | BIOPROJET SOC CIV (FR) | 2008-04-30 | — | — | CN | claimed |
| US-7312337-B2 | Oxadiazoles and their manufacture | EASTMAN KODAK COMPANY (US) | 2007-12-25 | — | — | US | claimed |
| US-7268235-B2 | Method for preparation of N-pyrazolylamidoximes | EASTMAN KODAK COMPANY (US) | 2007-09-11 | — | — | US | claimed |
| US-20060074245-A1 | Method for preparation of N-pyrazolylamidoximes | EASTMAN KODAK COMPANY | 2006-04-06 | — | — | US | claimed |
| US-20060069262-A1 | Oxadiazoles and their manufacture | EASTMAN KODAK COMPANY | 2006-03-30 | — | — | US | claimed |
| US-4689411-A | ANTIBIOTICS | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1987-08-25 | — | — | US | claimed |
| US-4603014-A | Thiazolinoazetidinone derivatives and process for the preparation of the same | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1986-07-29 | — | — | US | claimed |
| CN-114042070-A | Compounds as neuronal histamine receptor-3 antagonists and uses thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2022-02-15 | — | — | CN | disclosed |
| CN-112004802-B | Compounds as neuronal histamine receptor-3 antagonists and uses thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2021-12-28 | — | — | CN | disclosed |
| EP-3856719-A1 | COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF | XWPharma Ltd. (KY) | 2021-08-04 | — | — | EP | disclosed |
| CN-108084179-B | Compound with spiro structure, preparation method and application thereof | 上海医药工业研究院 | 2021-02-05 | — | — | CN | disclosed |
| CN-112004802-A | Compounds as neuronal histamine receptor-3 antagonists and uses thereof | 凯瑞康宁生物工程（武汉）有限公司 | 2020-11-27 | — | — | CN | disclosed |
| EP-0046590-B1 | PHEN(ALK)OXY-SUBSTITUTED OXIRANE-CARBOXYLIC ACIDS, PROCESS FOR THEIR PREPARATION, THEIR USE AND DRUGS CONTAINING THEM | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-05-22 | — | — | EP | disclosed |
| US-4482491-A | CHEMICAL INTERMEDIATES FOR CEPHALOSPORIN | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1984-11-13 | — | — | US | disclosed |
| US-4464237-A | ELECTROLYZING AZETIDINONE DERIVATIVES, CEPHALOSPORIN OR PENICILLIN INTERMEDIATES | OTSUKA KAGAKU YAKUHIN KABUSHIKI KAISHA (JP) | 1984-08-07 | — | — | US | disclosed |
| WO-1982000643-A1 | SUBSTITUTED OXIRANECARBONIC ACIDS,PREPARATION AND PHARMACEUTICAL UTILISATION THEREOF | BYK GULDEN LOMBERG CHEM FAB (DE) | 1982-03-04 | — | — | WO | disclosed |
| EP-0046590-A2 | Phen(alk)oxy-substituted oxirane-carboxylic acids, process for their preparation, their use and drugs containing them | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1982-03-03 | — | — | EP | disclosed |
| US-4108663-A | MULTILAYER | FUJI PHOTO FILM CO., LTD. (JP) | 1978-08-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069262-A1 | Oxadiazoles and their manufacture | OXA1L, CYP1B1, OXER1 | KCNH2 2258/4885DRD2 699/4885DRD4 1460/4885 |
| US-20060074245-A1 | Method for preparation of N-pyrazolylamidoximes | KCNH1, KCNJ2, KCNH2 | KCNH2 3/4885DRD2 1604/4885DRD4 1457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.