Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 6/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 4/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 4/20 | 1.00 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 1.00 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 1.00 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 1.00 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 1.00 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 1.00 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 1.00 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719842 | 0.90 | HDAC1 (0.81) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL719635 | 0.83 | HDAC1 (0.71) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL718972 | 0.83 | HDAC3 (0.70) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL721483 | 0.83 | HDAC3 (0.70) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL16906890 | 0.81 | HDAC1 (0.68) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL38661069 | 0.80 | APEX1 (0.70) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL719373 | 0.80 | HDAC1 (0.66) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL16716725 | 0.79 | HDAC1 (0.65) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL13748129 | 0.79 | HDAC1 (0.65) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL721440 | 0.79 | HDAC1 (0.65) | HDAC1HDAC2HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024189607-A1 | METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR DISEASES TREATMENT | DIDENKO KIRILL (MX) | 2024-09-19 | — | — | WO | disclosed |
| US-20230321130-A1 | Senolytic Compositions and Uses Thereof | Rubedo Life Sciences, Inc. | 2023-10-12 | — | — | US | disclosed |
| US-20230137021-A1 | Drug Conjugates of Sugar Derivatives and Uses Thereof as Senolytic Agents | Rubedo Life Sciences, Inc. | 2023-05-04 | — | — | US | disclosed |
| US-20230137021-A1 | Drug Conjugates of Sugar Derivatives and Uses Thereof as Senolytic Agents | Rubedo Life Sciences, Inc. | 2023-05-04 | — | — | US | disclosed |
| US-9381196-B2 | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-07-05 | — | — | US | disclosed |
| US-20150196559-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-07-16 | — | — | US | disclosed |
| US-8987468-B2 | Compounds, pharmaceutical compositions and methods of use of hydroxamic acid derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2015-03-24 | — | — | US | disclosed |
| US-20120053188-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE(TGEN (US) | 2012-03-01 | — | — | US | disclosed |
| WO-2009100045-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2009-08-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053188-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES | HDAC5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC4 | HDAC1 11/4885HDAC2 15/4885HDAC6 5/4885 |
| US-20230137021-A1 | Drug Conjugates of Sugar Derivatives and Uses Thereof as Senolytic Agents | AGER, SENP6, SENP3 | HDAC1 861/4885HDAC2 1138/4885HDAC6 275/4885 |
| US-20230321130-A1 | Senolytic Compositions and Uses Thereof | SENP3, SENP6, SENP1 | HDAC1 1056/4885HDAC2 1020/4885HDAC6 514/4885 |
| US-20150196559-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF HYDROXAMIC ACID DERIVATIVES | HDAC5, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HDAC4 | HDAC1 11/4885HDAC2 15/4885HDAC6 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.