Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | OGT | O15294 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207494 | 0.83 | TSHR (0.51) | HTTALDH1A1GAATSHRKMT2A | |
| SCHEMBL7209464 | 0.81 | HTT (0.55) | HTTALDH1A1GAATSHRPKM | |
| SCHEMBL7208549 | 0.78 | HTT (0.47) | HTTALDH1A1GAAHPGDTSHR | |
| SCHEMBL14601548 | 0.76 | HTT (0.75) | HTTALDH1A1TSHRMAPTPOLB | |
| SCHEMBL29597888 | 0.72 | GLA (0.53) | GAAMAPTPOLBLMNASMN1; SMN2 | |
| SCHEMBL11109645 | 0.72 | MAOB (0.38) | ALDH1A1GAAHPGDTSHRKMT2A | |
| SCHEMBL22590675 | 0.71 | PYCR1 (0.49) | ALDH1A1GAAHPGDTSHRKMT2A | |
| SCHEMBL31592654 | 0.71 | SIGMAR1 (0.49) | HTTALDH1A1MAPTLMNASMN1; SMN2 | |
| SCHEMBL8193976 | 0.71 | CA2 (0.59) | HTTALDH1A1GAATSHRPKM | |
| SCHEMBL2564265 | 0.71 | ALDH1A1 (0.47) | HTTALDH1A1GAAHPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | claimed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | claimed |
| EP-1045690-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 2000-10-25 | — | — | EP | claimed |
| WO-1999026616-A1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1999-06-03 | — | — | WO | claimed |
| EP-1045690-B1 | BENZENESULFONAMIDE INHIBITORS OF PDE-IV AND THEIR THERAPEUTIC USE | WARNER LAMBERT CO (US) | 2003-04-23 | — | — | EP | disclosed |
| US-6162830-A | Benzenesulfonamide inhibitors of PDE-IV and their therapeutic use | WARNER-LAMBERT COMPANY (US) | 2000-12-19 | — | — | US | disclosed |