Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL7204814

COC(=O)C(N)CC(=O)O.N

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.39
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
KIF11 P52732 1/20 0.36
BHMT Q93088 1/20 0.35
SLC1A1 P43005 1/20 0.35
S1PR1 P21453 1/20 0.35
S1PR3 Q99500 1/20 0.35
ALDH1A1 P00352 1/20 0.35
SLC22A6 Q4U2R8 1/20 0.35
GABRR1 P24046 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6259101 0.98 KMT2A (0.37) KMT2ASMN1; SMN2KIF11BHMTSLC1A1
SCHEMBL996039 0.98 KMT2A (0.37) KMT2ASMN1; SMN2KIF11BHMTSLC1A1
SCHEMBL416894 0.98 KMT2A (0.37) KMT2ASMN1; SMN2KIF11BHMTSLC1A1
Hydrochloric Acid SCHEMBL4678546 0.95 KMT2A (0.36) KMT2ASMN1; SMN2KIF11BHMTSLC1A1
Hydrochloric Acid SCHEMBL30466615 0.95 KMT2A (0.36) KMT2ASMN1; SMN2KIF11BHMTSLC1A1
Hydrochloric Acid SCHEMBL4678540 0.95 KMT2A (0.36) KMT2ASMN1; SMN2KIF11BHMTSLC1A1
SCHEMBL28364770 0.88 KIF11 (0.33) KMT2ASMN1; SMN2KIF11BHMTSLC1A1
SCHEMBL29069491 0.84 BHMT (0.35) TDP1KMT2ASMN1; SMN2BHMTSLC1A1
SCHEMBL8894673 0.80 SMN1; SMN2 (0.42) SMN1; SMN2KIF11SLC1A1ALDH1A1
SCHEMBL16775785 0.79 ALDH1A1 (0.40) TDP1KMT2ASMN1; SMN2KIF11SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0734252-B1 VINCA-ALKALOID VESICLES WITH ENHANCED EFFICACY AND TUMOR TARGETING PROPERTIES NEXSTAR PHARMACEUTICALS INC (US) 2003-04-16 EP disclosed
US-6120800-A TO CONTROL DELIVERY OF ENCAPSULATED ANTICANCER AGENTS TO TUMORS IN MAMMALS; DECREASED TOXICITY NEXSTAR PHARMACEUTICALS, INC. (US) 2000-09-19 US disclosed
US-5888537-A LIPOSOMES COMPRISED OF PHOSPHATIDYL CHOLINE, CHOLESTEROL AND PHOSPHATIDYL GLYCEROL, HAVING INTERNAL AQUEOUS PHASE CONTAINING CATIONIC VINCA ALKALOID AND ANION OF LOW MEMBRANE PERMEABILITY NEXSTAR PHARMACEUTICALS, INC. (US) 1999-03-30 US disclosed
US-5714163-A COMPRISING DISTEAROYLPHOSPHATIDYL CHOLINE, CHOLESTEROL AND DISTEAROYLPHOSPHATIDYL GLYCEROL NEXSTAR PHARMACEUTICALS, INC. (US) 1998-02-03 US disclosed
EP-0734252-A1 VINCA-ALKALOID VESICLES WITH ENHANCED EFFICACY AND TUMOR TARGETING PROPERTIES NeXstar Pharmaceuticals, Inc. (US) 1996-10-02 EP disclosed
WO-1996000057-A1 VINCA-ALKALOID VESICLES WITH ENHANCED EFFICACY AND TUMOR TARGETING PROPERTIES VESTAR, INC. (US) 1996-01-04 WO disclosed