Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.43 |
| ▸ | APEX1 | P27695 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12173199 | 0.83 | MEN1 (0.53) | APEX1NPSR1DNM1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6544618 | 0.76 | APEX1 (0.50) | APEX1NPSR1DNM1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL330118 | 0.75 | HTT (0.62) | DNM1KMT2ALMNAHSP90AA1RAD52 | |
| Hydrochloric Acid SCHEMBL6046691 | 0.72 | APEX1 (0.53) | APEX1NPSR1DNM1MEN1KMT2A | |
| SCHEMBL6544620 | 0.72 | MEN1 (0.47) | APEX1NPSR1DNM1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5399827 | 0.70 | APEX1 (0.50) | APEX1NPSR1DNM1MEN1KMT2A | |
| SCHEMBL10404934 | 0.70 | TSHR (0.31) | TSHR | |
| Hydrochloric Acid SCHEMBL4541161 | 0.69 | APEX1 (0.77) | APEX1NPSR1DNM1MEN1KMT2A | |
| SCHEMBL12173197 | 0.69 | MEN1 (0.50) | APEX1NPSR1DNM1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1339743 | 0.69 | APEX1 (0.42) | APEX1NPSR1DNM1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021388-B1 | PHOSPHORYLATION PROCESS AND CATALYST | BIONERIS AB (SE) | 2003-06-25 | — | — | EP | disclosed |
| US-6479656-B1 | Phosphorylation process and catalyst | PERSTORP AB (SE) | 2002-11-12 | — | — | US | disclosed |