Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208336 | 0.87 | HDAC3 (0.38) | CYP1A2CYP2D6NPSR1CES1MAPT | |
| SCHEMBL7207547 | 0.75 | L3MBTL1 (0.43) | PTGS2CES1MAPT | |
| SCHEMBL7206919 | 0.74 | CYP1A2 (0.41) | KCNN4CYP1A2CYP2D6PTGS2NPSR1 | |
| SCHEMBL7206377 | 0.72 | LMNA (0.37) | MAPT | |
| SCHEMBL7211246 | 0.70 | LMNA (0.47) | MAPTKMT2A | |
| SCHEMBL7207786 | 0.69 | CHRM2 (0.41) | CYP2D6NPSR1KMT2A | |
| SCHEMBL7211852 | 0.69 | HRH3 (0.42) | — | |
| SCHEMBL7206358 | 0.69 | HDAC3 (0.37) | CYP1A2KMT2A | |
| SCHEMBL7206890 | 0.67 | CHRM3 (0.44) | CYP1A2CYP2D6MAPTKMT2A | |
| SCHEMBL7211946 | 0.66 | CHRM3 (0.45) | CYP1A2CYP2D6MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |