Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 6/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208338 | 0.86 | HDAC3 (0.41) | CYP1A2CYP2D6CES1BCL2MCL1 | |
| SCHEMBL7212843 | 0.76 | CES2 (0.52) | CES1BCL2MCL1GABRA1GABRB1 | |
| SCHEMBL7206915 | 0.74 | KCNN4 (0.37) | CYP1A2CYP2D6KCNN4CES1BCL2 | |
| SCHEMBL1508202 | 0.72 | CES1 (0.56) | CYP1A2KCNN4CES1MAPTLMNA | |
| SCHEMBL15519395 | 0.72 | CES1 (0.56) | CYP1A2KCNN4CES1MAPTLMNA | |
| SCHEMBL7207551 | 0.72 | L3MBTL1 (0.56) | CES1GABRA1GABRB1MAPTPTGS1 | |
| SCHEMBL7211288 | 0.72 | PTGS2 (0.41) | CES1MAPTPTGS1CXCR1CXCR2 | |
| SCHEMBL7211116 | 0.72 | RAB9A (0.51) | MAPTSMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL7206391 | 0.71 | MAPT (0.47) | CES1MAPTSMN1; SMN2LMNAKDM4E | |
| SCHEMBL9408445 | 0.70 | ALDH1A1 (0.44) | CYP1A2CYP2D6SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |