Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 15/20 | 0.68 |
| ▸ | MMP1 | P03956 | 9/20 | 0.68 |
| ▸ | MMP8 | P22894 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207685 | 0.83 | MMP13 (0.51) | MMP13MMP1MMP8PKMMMP9 | |
| SCHEMBL7207764 | 0.81 | MMP13 (1.00) | MMP13MMP1MMP8PKMMMP9 | |
| SCHEMBL7212134 | 0.80 | MMP13 (1.00) | MMP13MMP1MMP8PKMMMP9 | |
| SCHEMBL7208713 | 0.79 | MMP13 (0.48) | MMP13MMP1MMP8MMP9ADAM17 | |
| SCHEMBL7208439 | 0.77 | MMP13 (1.00) | MMP13MMP1MMP8MMP9MMP2 | |
| SCHEMBL7208715 | 0.77 | MMP13 (0.46) | MMP13MMP1MMP9ADAM17MMP2 | |
| SCHEMBL7411621 | 0.77 | MMP13 (0.57) | MMP13MMP1MMP8PKMMMP9 | |
| SCHEMBL7509502 | 0.77 | MMP13 (0.51) | MMP13MMP1MMP8PKMMMP9 | |
| SCHEMBL4195254 | 0.76 | PKM (0.61) | MMP13MMP1MMP8PKMMMP9 | |
| SCHEMBL7212751 | 0.76 | MMP13 (0.82) | MMP13MMP1MMP8MMP9ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0939628-A4 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0939628-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003164-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |