Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.46 |
| ▸ | MMP9 | P14780 | 4/20 | 0.46 |
| ▸ | MMP1 | P03956 | 14/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 8/20 | 0.44 |
| ▸ | MMP3 | P08254 | 8/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 5/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208713 | 0.84 | MMP13 (0.48) | MMP13MMP9MMP1HTTNPSR1 | |
| SCHEMBL7207685 | 0.80 | MMP13 (0.51) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL7207026 | 0.77 | MMP13 (0.68) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL7208714 | 0.73 | MMP1 (0.48) | MMP13MMP9MMP1HTTNPSR1 | |
| SCHEMBL7207763 | 0.72 | MMP1 (0.49) | MMP13MMP9MMP1HTTNPSR1 | |
| SCHEMBL7207037 | 0.72 | MMP1 (0.55) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL8713408 | 0.71 | MMP1 (0.51) | MMP13MMP9MMP1HTTNPSR1 | |
| SCHEMBL7212083 | 0.71 | MMP13 (0.49) | MMP13MMP9MMP1HTTNPSR1 | |
| SCHEMBL8714771 | 0.71 | MMP13 (0.73) | MMP13MMP9MMP1MMP2MMP3 | |
| SCHEMBL4195254 | 0.70 | PKM (0.61) | MMP13MMP9MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |