Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 13/20 | 0.51 |
| ▸ | MMP1 | P03956 | 12/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 4/20 | 0.48 |
| ▸ | MMP2 | P08253 | 4/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207026 | 0.83 | MMP13 (0.68) | MMP13MMP1PKMMMP9MMP2 | |
| SCHEMBL7212155 | 0.81 | MMP1 (0.73) | MMP13MMP1PKMMMP9MMP2 | |
| SCHEMBL7208715 | 0.80 | MMP13 (0.46) | MMP13MMP1MMP9MMP2MMP3 | |
| SCHEMBL7207036 | 0.80 | MMP1 (0.74) | MMP13MMP1PKMMMP9MMP2 | |
| SCHEMBL7208713 | 0.79 | MMP13 (0.48) | MMP13MMP1MMP9MMP2MMP8 | |
| SCHEMBL28121988 | 0.79 | PRKDC (0.46) | MMP13MMP1CA1CA2 | |
| SCHEMBL7207037 | 0.78 | MMP1 (0.55) | MMP13MMP1PKMMMP9MMP2 | |
| SCHEMBL7207560 | 0.77 | MMP13 (0.75) | MMP13MMP1MMP9MMP2GAA | |
| SCHEMBL8714771 | 0.77 | MMP13 (0.73) | MMP13MMP1MMP9MMP2CA1 | |
| SCHEMBL4195254 | 0.76 | PKM (0.61) | MMP13MMP1PKMMMP9MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0939628-A4 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0939628-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003164-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |