SCHEMBL7509502

SCHEMBL7509502

COc1ccc(S(=O)(=O)C(N)CCN)cc1

nearest known ligand 0.51

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MMP13 P45452 12/20 0.51
MMP1 P03956 9/20 0.51
PKM P14618 3/20 0.48
MMP9 P14780 4/20 0.45
LOX P28300 1/20 0.43
ADAM17 P78536 2/20 0.43
MMP2 P08253 2/20 0.43
MMP3 P08254 1/20 0.43
ALDH1A1 P00352 1/20 0.42
PTGS2 P35354 1/20 0.42
F2 P00734 1/20 0.42
PRSS1 P07477 1/20 0.42
PRSS2 P07478 1/20 0.42
PRSS3 P35030 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
MMP8 P22894 1/20 0.42
GAA P10253 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL7078665 0.88 CA12 (0.46) MMP13MMP1MMP9MMP2MMP3
SCHEMBL7211320 0.81 PKM (0.50) MMP13MMP1PKMMMP9MMP2
SCHEMBL7201223 0.81 CA12 (0.45) ALDH1A1F2PRSS1PRSS2PRSS3
SCHEMBL7479917 0.81 MMP13 (0.47) MMP13MMP1MMP9ADAM17MMP2
SCHEMBL7080813 0.80 PKM (0.48) MMP13MMP1PKMMMP9MMP2
SCHEMBL7207026 0.77 MMP13 (0.68) MMP13MMP1PKMMMP9ADAM17
SCHEMBL29489155 0.73 CA1 (0.50) MMP13MMP1MMP9MMP2ALDH1A1
SCHEMBL7207685 0.73 MMP13 (0.51) MMP13MMP1PKMMMP9ADAM17
SCHEMBL13043584 0.72 MMP1 (0.85) MMP13MMP1PKMMMP9ADAM17
SCHEMBL4195254 0.72 PKM (0.61) MMP13MMP1PKMMMP9MMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927168-B1 1,3-DIHETEROCYCLIC METALLOPROTEASE INHIBITORS PROCTER & GAMBLE (US) 2002-11-06 EP disclosed
US-6469000-B1 TREATING ARTHRITIS, CANCER, CARDIOVASCULAR DISORDERS, SKIN DISORDERS, OCULAR DISORDERS, INFLAMMATION AND GUM DISEASE THE PROCTER & GAMBLE CO. 2002-10-22 US disclosed
US-6465474-B1 TREATMENT OF SUCH AS OSTEOARTHITIS, RHEUMATOID ARTHRITIS, PREVENTION OR ARREST OF TUMOR GROWTH AND METASTASIS, CORNEAL ULCERATION, LACK OF CORNEAL HEALING, MACULAR DEGENERATION, PERIODONTAL DISEASE, GINGIVITIS THE PROCTER & GAMBLE COMPANY 2002-10-15 US disclosed
US-6150370-A 1,3-DINITROCYCLIC COMPOUND TREATS NUMEROUS DISEASES CAUSED BY UNDESIRED METALLOPROTEASE ACTIVITY, SUCH AS TUMOR METASTASIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, SKIN INFLAMMATION, ULCERATIONS, AND PERIODONTITIS THE PROCTER & GAMBLE COMPANY (US) 2000-11-21 US disclosed