Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19435727 | 0.72 | HCAR2 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL19435724 | 0.72 | HCAR2 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL19435723 | 0.72 | HCAR2 (0.53) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL9686924 | 0.71 | HCAR2 (0.51) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL2123130 | 0.70 | NOS1 (0.41) | KDM4EALDH1A1LMNAMAPTMEN1 | |
| SCHEMBL29376183 | 0.69 | HCAR2 (0.41) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL5746594 | 0.68 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4913015 | 0.67 | RAB9A (0.56) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4913013 | 0.67 | RAB9A (0.56) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL19749 | 0.64 | ELANE (0.47) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610726-B2 | Pyrazole derivative that mimics or agonizes hepatocyte growth factor/scatter factor; antiischemic agents | NORTH SHORE-LONG ISLAND JEWISH RESEARCH INSTITUTE | 2003-08-26 | — | — | US | disclosed |