SCHEMBL7207566

SCHEMBL7207566

O=S(=O)(CCCS)c1ccccc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 4/20 0.71
MMP13 P45452 4/20 0.71
MMP3 P08254 3/20 0.71
MMP1 P03956 1/20 0.71
PSIP1 O75475 1/20 0.52
KEAP1 Q14145 1/20 0.51
NFE2L2 Q16236 1/20 0.51
ADAM17 P78536 2/20 0.50
HDAC1 Q13547 2/20 0.50
HDAC8 Q9BY41 2/20 0.50
HDAC3 O15379 1/20 0.50
HDAC4 P56524 1/20 0.50
HDAC7 Q8WUI4 1/20 0.50
HDAC2 Q92769 1/20 0.50
HDAC10 Q969S8 1/20 0.50
HDAC11 Q96DB2 1/20 0.50
HDAC6 Q9UBN7 1/20 0.50
HDAC9 Q9UKV0 1/20 0.50
HDAC5 Q9UQL6 1/20 0.50
MMP2 P08253 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11566606 0.94 MMP8 (0.64) MMP8MMP13MMP3MMP1PSIP1
SCHEMBL7212095 0.88 MMP13 (0.68) MMP8MMP13MMP3MMP1KEAP1
SCHEMBL1722036 0.86 PSIP1 (0.56) MMP8MMP13MMP3MMP1PSIP1
SCHEMBL10629823 0.86 PSIP1 (0.61) MMP8MMP13MMP3MMP1PSIP1
SCHEMBL576918 0.86 KEAP1 (0.63) MMP8MMP13MMP3MMP1PSIP1
SCHEMBL10626503 0.84 HDAC1 (0.65) MMP8MMP13MMP3MMP1PSIP1
SCHEMBL7208687 0.84 MMP13 (1.00) MMP8MMP13MMP3MMP1ADAM17
SCHEMBL7213456 0.84 MMP13 (1.00) MMP8MMP13MMP3MMP1KEAP1
SCHEMBL777601 0.81 PSIP1 (0.67) MMP8MMP13MMP3PSIP1KEAP1
SCHEMBL8972497 0.80 PSIP1 (0.54) MMP8MMP13MMP3MMP1PSIP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0939628-B1 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO CO (US) 2003-03-05 EP disclosed
US-6013649-A BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS MONSANTO COMPANY (US) 2000-01-11 US disclosed
EP-0939628-A4 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO CO (US) 1999-12-22 EP disclosed
EP-0939628-A1 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO COMPANY (US) 1999-09-08 EP disclosed
WO-1998003164-A1 THIOL SULFONE METALLOPROTEASE INHIBITORS MONSANTO COMPANY (US) 1998-01-29 WO disclosed