Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 12/20 | 0.49 |
| ▸ | MMP13 | P45452 | 10/20 | 0.49 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7214317 | 0.83 | ADAMTS5 (0.57) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7213014 | 0.81 | ADAMTS5 (0.65) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7212985 | 0.81 | MMP1 (0.51) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7207007 | 0.79 | ADAMTS5 (0.60) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7208577 | 0.79 | ADAM17 (0.39) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7214333 | 0.78 | MMP1 (0.48) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7208099 | 0.77 | MMP1 (0.52) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7214298 | 0.76 | MMP1 (0.49) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7208120 | 0.75 | MMP1 (0.52) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 | |
| SCHEMBL7214292 | 0.74 | MMP1 (0.49) | MMP1MMP13ADAMTS7ADAMTS5ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181285-B1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PROD INC (US) | 2003-10-08 | — | — | EP | disclosed |
| US-6342521-B1 | DRUGS FOR TREATMENT OF ARTHRITIS | PFIZER INC. | 2002-01-29 | — | — | US | disclosed |