Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.39 |
| ▸ | MMP1 | P03956 | 4/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | ADAMTS7 | Q9UKP4 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213016 | 0.82 | ADAMTS5 (0.51) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7212988 | 0.81 | MMP1 (0.41) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7207012 | 0.80 | MMP13 (0.49) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7208565 | 0.79 | MMP1 (0.49) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7214339 | 0.78 | MMP1 (0.40) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7214304 | 0.77 | MMP1 (0.37) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7212996 | 0.74 | MMP1 (0.42) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7209169 | 0.74 | MMP1 (0.43) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL7213084 | 0.72 | ADAMTS5 (0.40) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 | |
| SCHEMBL5492928 | 0.71 | ADAMTS5 (0.64) | ADAM17MMP1ADAMTS5MMP13ADAMTS7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181285-B1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PROD INC (US) | 2003-10-08 | — | — | EP | disclosed |
| US-6342521-B1 | DRUGS FOR TREATMENT OF ARTHRITIS | PFIZER INC. | 2002-01-29 | — | — | US | disclosed |