Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HRH2 | P25021 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658508 | 0.92 | MTNR1A (0.59) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL9808670 | 0.87 | GAA (0.66) | MAPTLMNAL3MBTL1MAPK1RAB9A | |
| SCHEMBL14901534 | 0.86 | L3MBTL1 (0.53) | MAPTLMNAL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL2405588 | 0.85 | POLB (0.60) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL10426837 | 0.85 | MAPT (0.62) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL15496878 | 0.84 | RARB (0.57) | MAPTLMNAL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL10030181 | 0.84 | L3MBTL1 (0.55) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL16597904 | 0.83 | NPC1 (0.68) | MAPTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL15084279 | 0.83 | GAA (0.66) | L3MBTL1TP53GAA | |
| SCHEMBL7012233 | 0.83 | L3MBTL1 (0.47) | MAPTLMNAL3MBTL1MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8535577-B2 | Photochromic materials that include 6-amino substituted indeno-fused naphthopyrans | TRANSITIONS OPTICAL, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-8277699-B2 | Photochromic materials that include 6-amino substituted indeno-fused naphthopyrans | Transistions Optical, Inc. (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120214992-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2012-08-23 | — | — | US | disclosed |
| US-20120053341-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | TRANSITIONS OPTICAL, INC. (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214992-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | NPEPPS, MITF, NR2E3 | MAPT 1148/4885LMNA 2621/4885L3MBTL1 2109/4885 |
| US-20120053341-A1 | PHOTOCHROMIC MATERIALS THAT INCLUDE 6-AMINO SUBSTITUTED INDENO-FUSED NAPHTHOPYRANS | MITF, NPEPPS, GNE | MAPT 1095/4885LMNA 1812/4885L3MBTL1 2074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.