Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 4/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.38 |
| ▸ | ESRRA | P11474 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16179448 | 0.81 | MRGPRX4 (0.42) | MRGPRX4ARTRPV4EPAS1TBXA2R | |
| SCHEMBL27804618 | 0.80 | ALDH1A1 (0.45) | ARCYP1A2EPAS1TBXA2RALDH1A1 | |
| SCHEMBL12129703 | 0.77 | ALPL (0.38) | TRPV4CA1CA2CA9ALPL | |
| SCHEMBL931494 | 0.76 | AR (0.60) | MRGPRX4ARESRRALRRK2ALDH1A1 | |
| SCHEMBL3859664 | 0.76 | TSHR (0.44) | CA1CA2CA9ALPLCYP1A2 | |
| SCHEMBL6937925 | 0.76 | CA1 (0.55) | CA1CA2CA9ALPLCYP1A2 | |
| SCHEMBL20129681 | 0.74 | MRGPRX4 (0.44) | MRGPRX4ARTRPV4CA1CA2 | |
| SCHEMBL1277294 | 0.73 | AR (0.45) | MRGPRX4ARTRPV4ESRRALRRK2 | |
| SCHEMBL13342828 | 0.73 | TSHR (0.47) | TRPV4ALPLCYP1A2TSHRHSD17B10 | |
| SCHEMBL11576553 | 0.73 | CYP1A2 (0.42) | CA1CA2CA9ALPLCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100379722-C | Compounds | ASTRA ZENECA LTD (SE) | 2008-04-09 | — | — | CN | disclosed |
| EP-1036061-B1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-09-24 | — | — | EP | disclosed |
| US-6337394-B2 | N-ACYL-HETEROCYCLE-CARBOXYAMIDES THAT ARE N-SUBSTITUTED WITH AMIDINO-SUBSTITUTED RINGS; COMPETITIVE INHIBITORS OF THROMBIN; ANTICOAGULANTS | ASTRAZENECA AB (SE) | 2002-01-08 | — | — | US | disclosed |
| US-20010046981-A1 | COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 2001-11-29 | — | — | US | disclosed |
| CN-1284063-A | Compounds | ASTRA ZENECA LTD (SE) | 2001-02-14 | — | — | CN | disclosed |
| EP-1036061-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029664-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010046981-A1 | COMPOUNDS | F2, SERPINC1, SERPINB1 | MRGPRX4 931/4885AR 3242/4885TRPV4 4329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.