Water

Water

SCHEMBL7210787

O.O.O=[N+]([O-])c1ccc(S(=O)(=O)O)c([N+](=O)[O-])c1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.57
KMT2A Q03164 2/20 0.57
ALDH1A1 P00352 5/20 0.55
MAPK1 P28482 3/20 0.55
HIF1A Q16665 2/20 0.55
CYP1A2 P05177 2/20 0.55
CYP2C19 P33261 2/20 0.55
CYP3A4 P08684 1/20 0.55
CYP2D6 P10635 1/20 0.55
CYP2C9 P11712 1/20 0.55
GPR35 Q9HC97 3/20 0.55
TSHR P16473 2/20 0.55
TP53 P04637 1/20 0.55
HPGD P15428 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
TDP1 Q9NUW8 2/20 0.52
NT5E P21589 2/20 0.50
GUSB P08236 1/20 0.49
TXNRD1 Q16881 1/20 0.49
TXNRD3 Q86VQ6 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL20573516 1.00 KMT2A (0.57) KMT2AMEN1ALDH1A1MAPK1HIF1A
Water SCHEMBL29684003 1.00 KMT2A (0.57) KMT2AMEN1ALDH1A1MAPK1HIF1A
SCHEMBL63183 0.98 KMT2A (0.59) KMT2AMEN1ALDH1A1MAPK1HIF1A
SCHEMBL1363964 0.98 KMT2A (0.59) KMT2AMEN1ALDH1A1MAPK1HIF1A
SCHEMBL3660349 0.96 KMT2A (0.61) KMT2AMEN1ALDH1A1MAPK1HIF1A
SCHEMBL11572072 0.96 KMT2A (0.57) KMT2AMEN1ALDH1A1MAPK1HIF1A
SCHEMBL11572065 0.96 KMT2A (0.57) KMT2AMEN1ALDH1A1MAPK1HIF1A
SCHEMBL3148713 0.96 KMT2A (0.57) KMT2AMEN1ALDH1A1MAPK1HIF1A
Hydrochloric Acid SCHEMBL4449301 0.96 KMT2A (0.57) KMT2AMEN1ALDH1A1MAPK1HIF1A
Bromide SCHEMBL27497723 0.96 KMT2A (0.57) KMT2AMEN1ALDH1A1MAPK1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112062773-B Method for acid-catalyzed cyclization reaction of 4-hydroxycoumarin and isoprene 中国科学院大连化学物理研究所 2021-11-26 CN claimed
CN-112920156-A Method for acid-catalyzed ring 1, 3-diketone isoamylene reaction 中国科学院大连化学物理研究所 2021-06-08 CN claimed
CN-112062773-A Method for acid-catalyzed cyclization reaction of 4-hydroxycoumarin and isoprene 中国科学院大连化学物理研究所 2020-12-11 CN claimed
CN-105482577-A Durable environment-friendly latex paint and preparation method thereof QU SHAOCHUN 2016-04-13 CN claimed
US-6495243-B1 Recording substrates for ink jet printing XEROX CORPORATION 2002-12-17 US claimed
US-6372030-B1 INK VEHICLE SELECTED FROM 4-(HEXADECYLAMINO)BENZYLAMINE, N-OCTANOYL-N-METHYL GLUCAMINE, OCTANOIC HYDRAZIDE, 4-HEXADECYL SULFONYL ANILINE, A CONDUCTIVE COMPLEX OF AN AMINE COMPOUND WITH A PHOSPHORUS OR SULFUR-CONTAINING ACID XEROX CORPORATION 2002-04-16 US claimed
WO-2025137439-A2 ENGINEERED T CELLS INTELLIA THERAPEUTICS, INC. (US) 2025-06-26 WO disclosed
CN-112920156-B Method for acid-catalyzed ring 1,3-diketone isoamylene reaction 中国科学院大连化学物理研究所 2023-02-28 CN disclosed
CN-112062773-B Method for acid-catalyzed cyclization reaction of 4-hydroxycoumarin and isoprene 中国科学院大连化学物理研究所 2021-11-26 CN disclosed
CN-112920156-A Method for acid-catalyzed ring 1, 3-diketone isoamylene reaction 中国科学院大连化学物理研究所 2021-06-08 CN disclosed
CN-112062773-A Method for acid-catalyzed cyclization reaction of 4-hydroxycoumarin and isoprene 中国科学院大连化学物理研究所 2020-12-11 CN disclosed
CN-105482577-A Durable environment-friendly latex paint and preparation method thereof QU SHAOCHUN 2016-04-13 CN disclosed
US-6509393-B2 Phase change inks XEROX CORPORATION 2003-01-21 US disclosed
US-5196411-A 17β-acyl-3-carboxy-androsta-3,5-dienes as testosterone 5α-reductase inhibitors MERCK & CO., INC. (US) 1993-03-23 US disclosed
EP-0528485-A1 17Beta-acyl-3-androsta-3,5-dienes as testosterone 5alpha-reductase inhibitors MERCK & CO. INC. (US) 1993-02-24 EP disclosed
US-5091380-A N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors MERCK & CO., INC. (US) 1992-02-25 US disclosed
EP-0465142-A1 17Beta-acyl-3-carboxy-androsta-3, 5-dienes as testosterone 5alpha-reductase inhibitors MERCK & CO. INC. (US) 1992-01-08 EP disclosed
EP-0465141-A2 N-monosubstituted adamantyl/norbornanyl 17beta-carbamides of3-carboxy-androst-3,5-dienes MERCK & CO. INC. (US) 1992-01-08 EP disclosed
EP-0465123-A2 New intermediates in the synthesis of 17beta-acyl-3-carboxy-androsta-3,5-dienes MERCK & CO. INC. (US) 1992-01-08 EP disclosed
US-5075450-A Intermediates in the synthesis of 17β-acyl-3-carboxy-androsta-3,5-dienes MERCK & CO., INC. (US) 1991-12-24 US disclosed