Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | POLA1 | P09884 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905399 | 1.00 | RXRA (0.34) | RXRAPPARGNR1H3POLA1CNR2 | |
| SCHEMBL7212192 | 0.85 | RXRA (0.33) | RXRAPPARGNR1H3CNR2CNR1 | |
| SCHEMBL7212191 | 0.83 | RXRA (0.41) | RXRAPPARGNR1H3ALDH1A1 | |
| SCHEMBL7212117 | 0.80 | RXRA (0.33) | RXRAPPARGNR1H3 | |
| SCHEMBL7207118 | 0.77 | RXRA (0.45) | RXRAPPARG | |
| SCHEMBL8904568 | 0.75 | RXRA (0.35) | RXRACNR2ALDH1A1CNR1 | |
| SCHEMBL8597944 | 0.75 | RXRA (0.37) | RXRA | |
| SCHEMBL7207907 | 0.74 | RXRA (0.47) | RXRAPPARGNR1H3KDM4EALDH1A1 | |
| SCHEMBL278733 | 0.69 | LMNA (0.44) | KDM4EALDH1A1 | |
| SCHEMBL31078471 | 0.69 | LMNA (0.44) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| US-5700836-A | TOPICALLY ADMINISTERING TO TREAT PHOTODAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1997-12-23 | — | — | US | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |