Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 13/20 | 0.44 |
| ▸ | CES1 | P23141 | 11/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211283 | 0.77 | PTGS2 (0.40) | CES2CES1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7207547 | 0.77 | L3MBTL1 (0.43) | CES2CES1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7212843 | 0.75 | CES2 (0.52) | CES2CES1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL10440558 | 0.71 | CES2 (0.56) | CES2CES1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL7206358 | 0.71 | HDAC3 (0.37) | — | |
| Benzil SCHEMBL28144199 | 0.69 | CES2 (0.74) | CES2CES1LMNAMAPTSMN1; SMN2 | |
| Benzil SCHEMBL28706871 | 0.68 | CES2 (0.64) | CES2CES1LMNAMAPTSMN1; SMN2 | |
| Benzil SCHEMBL11293167 | 0.67 | CES2 (0.70) | CES2CES1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL8574337 | 0.67 | CES2 (0.78) | CES2CES1MAPTRAB9AALDH1A1 | |
| Benzil SCHEMBL4832229 | 0.66 | CES2 (0.88) | CES2CES1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841913-B1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER LAMBERT CO (US) | 2003-02-05 | — | — | EP | claimed |
| EP-0841913-A1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER-LAMBERT COMPANY (US) | 1998-05-20 | — | — | EP | claimed |
| WO-1997005868-A1 | USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS | WARNER-LAMBERT COMPANY (US) | 1997-02-20 | — | — | WO | claimed |