Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LAP3 | P28838 | 2/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31343122 | 0.89 | KDM4E (0.40) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL6553514 | 0.87 | LAP3 (0.36) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL781267 | 0.86 | KDM4E (0.38) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL20162518 | 0.86 | KDM4E (0.38) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7208511 | 0.82 | LAP3 (0.39) | KDM4ETDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL6555636 | 0.82 | ALDH1A1 (0.38) | KDM4EALDH1A1L3MBTL1LAP3LMNA | |
| SCHEMBL5049712 | 0.75 | KDM4E (0.38) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL22321965 | 0.73 | KDM4E (0.36) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL382026 | 0.73 | KDM4E (0.36) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL28173097 | 0.71 | KDM4E (0.40) | KDM4ETDP1CHRNB2CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150988-B1 | PHOSPHORAMIDATE, AND MONO-, DI-, AND TRI-PHOSPHATE ESTERS OF (1R, CIS)-4-(6-AMINO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL AS ANTIVIRAL AGENTS | GLAXO GROUP LTD (GB) | 2003-05-28 | — | — | EP | claimed |