Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | KDM5A | P29375 | 2/20 | 0.46 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.46 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.39 |
| ▸ | TET3 | O43151 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.39 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325352 | 0.79 | KDM4E (0.55) | TDP1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL2833446 | 0.77 | CRHR1 (0.43) | — | |
| SCHEMBL27797493 | 0.75 | TDP1 (0.35) | TDP1KDM4EMAPTACACBMEN1 | |
| SCHEMBL6981215 | 0.75 | HRH3 (0.45) | TDP1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL9952304 | 0.74 | KDM4E (0.49) | TDP1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL9943692 | 0.74 | ALDH1A1 (0.67) | KDM4EKDM5AKDM3AALDH1A1ALOX15 | |
| SCHEMBL1180064 | 0.74 | KDM4E (0.48) | TDP1KDM4EALDH1A1ALOX15TSHR | |
| SCHEMBL29825918 | 0.72 | KDM4E (0.47) | TDP1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL2012249 | 0.71 | MAPK8 (0.52) | TDP1KDM4EKDM5AKDM3AJMJD1C | |
| SCHEMBL7492564 | 0.71 | KDM4E (0.55) | TDP1KDM4EALOX15TSHRACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6509361-B1 | Inhibit the activity of p38 MAP kinase. Also contemplated by the invention are processes for the preparation of the contemplated compounds and for the use of a contemplated compound in treating a mammalian host having a p38 kinase or | PHARMACIA CORPORATION | 2003-01-21 | — | — | US | disclosed |
| EP-1077971-A1 | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058523-A1 | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE & CO. (US) | 1999-11-18 | — | — | WO | disclosed |