Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645184 | 0.95 | CYP4F2 (0.59) | CYP4F2CYP4A11KMT2AALDH1A1GAA | |
| SCHEMBL1124854 | 0.85 | ALDH1A1 (0.47) | KMT2AALDH1A1GAAGFERHSP90AB1 | |
| SCHEMBL1799986 | 0.85 | TRIM24 (0.54) | CYP4F2CYP4A11KMT2AALDH1A1GAA | |
| SCHEMBL4113212 | 0.81 | CYP4F2 (0.76) | CYP4F2CYP4A11KMT2AALDH1A1GAA | |
| SCHEMBL14404459 | 0.81 | SMN1; SMN2 (0.69) | KMT2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL1428025 | 0.80 | LMNA (0.62) | CYP4F2CYP4A11KMT2AALDH1A1GAA | |
| SCHEMBL6301861 | 0.80 | CYP4F2 (0.59) | CYP4F2CYP4A11KMT2AALDH1A1GAA | |
| SCHEMBL15804409 | 0.80 | CYP4F2 (0.59) | CYP4F2CYP4A11KMT2AALDH1A1GAA | |
| SCHEMBL14394758 | 0.80 | CYP4F2 (0.47) | CYP4F2CYP4A11KMT2AALDH1A1GAA | |
| SCHEMBL1803272 | 0.79 | CYP4Z1 (0.56) | CYP4F2CYP4A11KMT2AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335899-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | Actelion Pharmaceuticals Ltd. (CH) | 2003-08-20 | — | — | EP | disclosed |
| WO-2002038534-A2 | SUBSTITUTED ALKYLDIAMINES AS INHIBITORS OF PLASMEPSIN OR RELATED PROTEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2002-05-16 | — | — | WO | disclosed |